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ABSTRACT Introduction: There are dozens of drugs in development for AD with billions of dollars invested. Despite the massive… Expand Latrepirdine (Dimebon) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to… Expand Increasing evidences suggest that mitochondrial dysfunction plays an important role in the pathogenesis of neurodegenerative… Expand Mitochondrial dysfunction has long been associated with neurodegenerative disease. Therefore, mitochondrial protective agents… Expand Huntington's disease (HD) is an autosomal, dominantly inherited neurodegenerative disorder, characterized by chorea, involuntary… Expand OBJECTIVE
The aim of this article was to provide a survey of the clinical development of pharmacotherapy for Alzheimer's disease… Expand BACKGROUND
Although treatments for Alzheimer's disease sometimes improve cognition, functional ability, or behaviour compared… Expand Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced… Expand Abstract: Mitochondrial permeability transition pores represent a multiprotein complex that includes components of both inner and… Expand Abstract: Dimebon, launched earlier in Russia as an antihistamine drug, was evaluated as a representative of a new generation of… Expand