latrepirdine

Known as: 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)-ethyl)-1H-pyrid(4,3b)indole, dimebone, Dimebon 
 
National Institutes of Health

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Review
2015
Review
2015
Latrepirdine for Alzheimer's disease.
BACKGROUND Current treatments for Alzheimer's disease (AD) provide modest symptomatic relief but do not slow the progression of… (More)
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2013
2013
Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer's mouse model
Latrepirdine (Dimebon) is a pro-neurogenic, antihistaminic compound that has yielded mixed results in clinical trials of mild to… (More)
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2013
2013
Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain
Latrepirdine (Dimebon; dimebolin) is a neuroactive compound that was associated with enhanced cognition, neuroprotection and… (More)
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2012
2012
Latrepirdine (dimebon) enhances autophagy and reduces intracellular GFP-Aβ42 levels in yeast.
Latrepirdine (Dimebon), an anti-histamine, has shown some benefits in trials of neurodegenerative diseases characterized by… (More)
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2012
2012
Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression
The prevalence of depression increases with aging. We hypothesized that like humans, old animals exhibit anhedonic-like behavior… (More)
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2010
2010
A randomized, placebo-controlled trial of latrepirdine in Huntington disease.
OBJECTIVES To evaluate the safety and tolerability of latrepirdine in Huntington disease (HD) and explore its effects on… (More)
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Review
2010
Review
2010
Phosphorylated and cleaved TDP-43 in ALS, FTLD and other neurodegenerative disorders and in cellular models of TDP-43 proteinopathy.
Transactivation response (TAR) DNA-binding protein of Mr 43 kDa (TDP-43) is a major component of the tau-negative and ubiquitin… (More)
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2009
2009
Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities.
Dimebolin (Dimebon), is a non-selective antihistamine approved in Russia for the treatment of allergy. Recently, this drug has… (More)
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2008
2008
Hope in Alzheimer's fight emerges from unexpected places
In drug development, sometimes you find what you’re not looking for. In July, at the annual meeting of the Alzheimer’s… (More)
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Highly Cited
2008
Highly Cited
2008
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
BACKGROUND Although treatments for Alzheimer's disease sometimes improve cognition, functional ability, or behaviour compared… (More)
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