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latrepirdine

Known as: 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)-ethyl)-1H-pyrid(4,3b)indole, dimebone, Dimebon 
 
National Institutes of Health

Papers overview

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Review
2012
Review
2012
Increasing evidences suggest that mitochondrial dysfunction plays an important role in the pathogenesis of neurodegenerative… Expand
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Highly Cited
2012
Highly Cited
2012
We previously reported the discovery of P7C3, an aminopropyl carbazole having proneurogenic and neuroprotective properties in… Expand
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Highly Cited
2009
Highly Cited
2009
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD‐U) are major… Expand
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Review
2009
Review
2009
Huntington's disease (HD) is an autosomal, dominantly inherited neurodegenerative disorder, characterized by chorea, involuntary… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Although treatments for Alzheimer's disease sometimes improve cognition, functional ability, or behaviour compared… Expand
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Highly Cited
2008
Highly Cited
2008
  • T. Gura
  • Nature Medicine
  • 2008
  • Corpus ID: 205381857
In drug development, sometimes you find what you’re not looking for. In July, at the annual meeting of the Alzheimer’s… Expand
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Highly Cited
2004
Highly Cited
2004
Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced… Expand
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Highly Cited
2004
Highly Cited
2004
Dimebon, a Russian-made drug, inhibited toxic effects of beta -amyloid on cultured neurons. Excessive accumulation of beta… Expand
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Highly Cited
2003
Highly Cited
2003
Abstract: Mitochondrial permeability transition pores represent a multiprotein complex that includes components of both inner and… Expand
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Highly Cited
2001
Highly Cited
2001
Abstract: Dimebon, launched earlier in Russia as an antihistamine drug, was evaluated as a representative of a new generation of… Expand
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