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latrepirdine

Known as: 2,3,4,5-tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)-ethyl)-1H-pyrid(4,3b)indole, dimebone, Dimebon 
National Institutes of Health

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Papers overview

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2013
2013
Evidence for the efficacy of latrepirdine (Dimebon) treatment for improvement of cognitive function: a meta-analysis.
Over the last few years, latrepirdine, a démodé antihistamine drug, has been proposed to be useful for treating neurodegenerative… 
2013
2013
The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti‐Alzheimer Multitarget Profile of Dimebon
Alzheimer’s disease (AD) is an extremely challenging and often frustrating area of drug discovery. Since the withdrawal of… 
Review
2012
Review
2012
Proteinopathies, neurodegenerative disorders with protein aggregation-based pathology
A number of neurodegenerative disorders were recently coalesced into a group of proteinopathies based on the similarity of… 
2012
2012
A quantitative way to estimate clinical off-target effects for human membrane brain targets in CNS research and development
Although many preclinical programs in central nervous system research and development intend to develop highly selective and… 
Highly Cited
2011
Highly Cited
2011
Ruthenium-catalyzed γ-carbolinium ion formation from aryl azides; synthesis of dimebolin.
A range of γ-carbolines were produced stereoselectively from ruthenium(III)-catalyzed reactions of 3-pyridyl substituted aryl… 
Highly Cited
2010
Highly Cited
2010
From anti-allergic to anti-Alzheimer's: Molecular pharmacology of Dimebon.
Dimebon, originally developed as an anti-histamine drug, is being re-purposed for new indications as an effective treatment for… 
2010
2010
Synthesis and biological activity of 5-styryl and 5-phenethyl-substituted 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indoles.
2008
2008
Dimebon in Alzheimer's disease: old drug for new indication
Highly Cited
2003
Highly Cited
2003
Comparative Study of Action Mechanisms of Dimebon and Memantine on AMPA- and NMDA-Subtypes Glutamate Receptors in Rat Cerebral Neurons
Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced… 
Highly Cited
2000
Highly Cited
2000
Dimebon improves learning in animals with experimental Alzheimer's disease
Systemic administration of antihistamine drug dimebon improves active avoidance conditioning in rats with chronic partial… 
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