• Publications
  • Influence
Antihistamine Agent Dimebon As a Novel Neuroprotector and a Cognition Enhancer
Abstract: Dimebon, launched earlier in Russia as an antihistamine drug, was evaluated as a representative of a new generation of anti‐Alzheimer's drugs that have two beneficial actions: (1) toExpand
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Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends
Alzheimer's disease (AD) is characterized by a chronic and progressive neurodegenerative process resulting from the intracellular and extracellular accumulation of fibrillary proteins: beta‐amyloidExpand
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Mitochondria as a Target for Neurotoxins and Neuroprotective Agents
Abstract: Mitochondrial permeability transition pores represent a multiprotein complex that includes components of both inner and outer membrane. The pores regulate transport of ions and peptides inExpand
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Comparative Study of Action Mechanisms of Dimebon and Memantine on AMPA- and NMDA-Subtypes Glutamate Receptors in Rat Cerebral Neurons
Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced only an insignificant potentiation in a small group of these cells.Expand
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Fused in Sarcoma (FUS) Protein Lacking Nuclear Localization Signal (NLS) and Major RNA Binding Motifs Triggers Proteinopathy and Severe Motor Phenotype in Transgenic Mice* ♦
Background: FUS inclusions are hallmarks of certain neurodegenerative diseases. Results: Expression of a highly aggregate prone FUS variant in transgenic mice causes proteinopathy and severe motorExpand
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Methylene blue and dimebon inhibit aggregation of TDP‐43 in cellular models
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitinated inclusions (FTLD‐U) are major neurodegenerative diseases with TDP‐43 pathology. Here we investigated theExpand
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Quinone reductase 2 and antidepressant effect of melatonin derivatives
Melatonin and its immediate precursor, N‐acetylserotonin (NAS), exert antidepressant effects in experimental models and clinical studies. We reported that melatonin and NAS decreased immobility timeExpand
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Medicinal chemistry approaches for the treatment and prevention of Alzheimer's disease
  • S. Bachurin
  • Medicine
  • Medicinal research reviews
  • 1 January 2003
Alzheimer's disease (AD) is the most common form of dementia, which is characterised by progressive deterioration of memory and higher cortical functions that ultimately result in total degradationExpand
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Toxicity of nanosilver in intragastric studies: Biodistribution and metabolic effects.
The unique physicochemical properties of silver nanoparticles explain their extensive application in consumer goods, food, and medicinal products. However, the biological effects of nanosilver afterExpand
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Chronic administration of dimebon ameliorates pathology in TauP301S transgenic mice.
Dimebon belongs to a fast-growing group of "old" drugs that were suggested to be effective for therapy of pathological conditions different from their original targets. Following initial reports ofExpand
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