lasonolide A

Genetic screens in cultured human cells represent a powerful unbiased strategy to identify cellular pathways that determine drug… Expand

Lasonolide A (LSA), a potent antitumor polyketide from the marine sponge, Forcepia sp., induces rapid and reversible protein… Expand

Lasonolide A is a novel polyketide displaying potent anticancer activity across a broad range of cancer cell lines. Here, an… Expand

Total synthetic studies on natural products with promising biological profiles, coupled with their intriguing structural features… Expand

Lasonolide A (LSA) is a natural product with high and selective cytotoxicity against mesenchymal cancer cells, including leukemia… Expand

Lasonolide A, a novel polyketide-derived macrolide, was previously identified from an extract of the marine sponge Forcepia sp… Expand

 

Homolasonolide A and 10-desmethyllasonolide A are biologically less active than lasonolide A. The ethyl ester analogue of… Expand

The proposed structure of lasonolide A was synthesized employing radical cyclization reactions of beta-alkoxyacrylates for… Expand

Total synthesis of the unnatural (-)-enantiomer of lasonolide A was achieved starting from ethyl l-malate. The two… Expand