lactate dehydrogenase A

Known as: LDH-A, LDH-M 
 
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
The lactate dehydrogenase-A (LDH-A) enzyme catalyzes the interconversion of pyruvate and lactate, is upregulated in human cancers… (More)
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Highly Cited
2013
Highly Cited
2013
Tumor cells commonly have increased glucose uptake and lactate accumulation. Lactate is produced from pyruvate by lactate… (More)
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Highly Cited
2012
Highly Cited
2012
In previous studies, lactate dehydrogenase A (LDHA) was identified as one of the leading genes that promote the proliferative and… (More)
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Highly Cited
2011
Highly Cited
2011
The Warburg effect describes an increase in aerobic glycolysis and enhanced lactate production in cancer cells. Lactate… (More)
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Highly Cited
2010
Highly Cited
2010
As the result of genetic alterations and tumor hypoxia, many cancer cells avidly take up glucose and generate lactate through… (More)
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Highly Cited
2009
Highly Cited
2009
Taxol is one of the most effective chemotherapeutic agents for the treatment of patients with breast cancer. Despite impressive… (More)
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Highly Cited
2006
Highly Cited
2006
Alterations in cellular metabolism are among the most consistent hallmarks of cancer. Herein we have investigated the… (More)
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Highly Cited
1999
Highly Cited
1999
Previous investigations revealed low activities of lactate dehydrogenase (LDH) and plasma membrane monocarboxylate transporters… (More)
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Highly Cited
1997
Highly Cited
1997
Cancer cells are able to overproduce lactic acid aerobically, whereas normal cells undergo anaerobic glycolysis only when… (More)
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Highly Cited
1994
Highly Cited
1994
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1… (More)
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