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kethoxal

Known as: 3-ethoxy-2-oxobutyraldehyde, Chetossale, 3-ethoxy-1,1-dihydroxy-2-butanone 
An agent that reacts with guanine to create a covalent adduct. In vivo, Kethoxal reacts with 30S ribosomal subunits yielding inactive ribosomes.
National Institutes of Health

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2 relations

Broader (2)

AldehydesAntiviral Agents

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Highly Cited
1979
Highly Cited
1979
Mechanism of ribosomal subunit association: discrimination of specific sites in 16 S RNA essential for association activity.
Highly Cited
1978
Highly Cited
1978
Structure-function correlations in the reaction of bis(thiosemicarbazonato) copper(II) complexes with Ehrlich ascites tumor cells.
Examination of a series of substituted bis(thiosemicarbazonato) copper(II) complexes shows that their reaction with Ehrlich… 
Highly Cited
1978
Highly Cited
1978
Initial reaction of 3-ethyoxy-2-oxobutyraldehyde bis(thiosemicarbazonato) copper(II) with Ehrlich ascites tumor cells.
The antineoplastic agent, 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazonato) copper(II), undergoes a pseudo-first-order… 
1976
1976
Identification of a 16S RNA sequence located in the decoding site of 30S ribosomes
1976
1976
Reactions of bis(thiosemicarbazonato) copper(II) complexes with tumor cells and mitochondria.
1974
1974
Comparative properties of the antineoplastic agent, 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazonato) copper(II) and related chelates: linear free energy correlations.
1974
1974
The crystal structure of the natitumor agent 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazonato) Copper(II).
1974
1974
Letters to the editor: Accessibility of 5 S RNA in 50 S ribosomal subunits.
Highly Cited
1973
Highly Cited
1973
Effect of heavy metals on the in vitro cytotoxicity of 3-ethoxy-2-oxobutyraldehyde bis (thiosemicarbazone) and related compounds.
Highly Cited
1967
Highly Cited
1967
The antitumor activity of Cu(II)KTS, the copper (II) chelate of 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone).
Summary The antitumor activity of the copper(II) chelate of 3-ethoxy-2-oxobutyraldehyde bis(thiosemicarbazone), Cu(II)KTS… 
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