kethoxal

Known as: 3-ethoxy-2-oxobutyraldehyde, Chetossale, 3-ethoxy-1,1-dihydroxy-2-butanone 
An agent that reacts with guanine to create a covalent adduct. In vivo, Kethoxal reacts with 30S ribosomal subunits yielding inactive ribosomes.
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
A dynamic programming algorithm for prediction of RNA secondary structure has been revised to accommodate folding constraints… (More)
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1990
1990
Saturated and unsaturated phosphatidylcholine (PC)-cholesterol membranes have been studied, with a special attention paid to… (More)
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Highly Cited
1987
Highly Cited
1987
Using dimethyl sulfate and kethoxal, we have probed antibiotic-ribosome complexes, and identified sites of interaction of… (More)
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Highly Cited
1986
Highly Cited
1986
We have investigated in detail the higher-order structure of 16 S ribosomal RNA, both in its naked form and in 30 S ribosomal… (More)
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Highly Cited
1982
Highly Cited
1982
A new tester strain, TA102, is described as an addition to the set of strains for the Salmonella/microsome mutagenicity test… (More)
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Highly Cited
1980
Highly Cited
1980
We have derived a secondary structure model for 16S ribosomal RNA on the basis of comparative sequence analysis, chemical… (More)
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Highly Cited
1980
Highly Cited
1980
Several transition series metals (copper, cadmium, zinc and mercury) and the sulfhydryl reagent, sodium arsenite, enhance the… (More)
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1972
1972
Kethoxal reacts with 30S ribosomal subunits to give totally inactive particles, as measured by in vitro protein synthesis. It is… (More)
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1965
1965
sarcoma 256 (W-256) and caused this tumor to regress in several cases (17). More recently, in rats bearing the W-256 tumor, KTS… (More)
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1965
1965
was markedly inhibited by kethoxal bis(thiosemicarbazone). After discontinuation of treatment the inhibition was persistent and… (More)
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