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Crystal Structure of the Ribosome at 5.5 Å Resolution
We describe the crystal structure of the complete Thermus thermophilus 70S ribosome containing bound messenger RNA and transfer RNAs (tRNAs) at 5.5 angstrom resolution. All of the 16S, 23S, and 5S… Expand
Complete nucleotide sequence of a 16S ribosomal RNA gene from Escherichia coli.
- J. Brosius, M. L. Palmer, P. J. Kennedy, H. Noller
- Medicine, Biology
- Proceedings of the National Academy of Sciences…
- 1 October 1978
The complete nucleotide sequence of the 16S RNA gene from the rrnB cistron of Escherichia coli has been determined by using three rapid DNA sequencing methods. Nearly all of the structure has been… Expand
Gene organization and primary structure of a ribosomal RNA operon from Escherichia coli.
- J. Brosius, T. Dull, D. D. Sleeter, H. Noller
- Biology, Medicine
- Journal of molecular biology
- 1 May 1981
The primary structure of the Escherichia coli rrnB ribosomal RNA operon has been determined. The sequence contains the genes for 16 S, 23 S and 5 S ribosomal RNAs, the secondary prophage site for… Expand
Crystal structure of the ribosome at 5
Intermediate states in the movement of transfer RNA in the ribosome
Direct chemical 'footprinting' shows that translocation of transfer RNA occurs in two discrete steps. During the first step, which occurs spontaneously after the formation of the peptide bond, the… Expand
Structural basis for translation termination on the 70S ribosome
- M. Laurberg, H. Asahara, A. Korostelev, J. Zhu, S. Trakhanov, H. Noller
- Biology, Medicine
- 14 August 2008
At termination of protein synthesis, type I release factors promote hydrolysis of the peptidyl-transfer RNA linkage in response to recognition of a stop codon. Here we describe the crystal structure… Expand
X-ray crystal structures of 70S ribosome functional complexes.
- J. Cate, M. Yusupov, G. Yusupova, T. Earnest, H. Noller
- Medicine, Materials Science
- 24 September 1999
Structures of 70S ribosome complexes containing messenger RNA and transfer RNA (tRNA), or tRNA analogs, have been solved by x-ray crystallography at up to 7.8 angstrom resolution. Many details of the… Expand
Spontaneous intersubunit rotation in single ribosomes.
During the elongation cycle, tRNA and mRNA undergo coupled translocation through the ribosome catalyzed by elongation factor G (EF-G). Cryo-EM reconstructions of certain EF-G-containing complexes led… Expand
Crystal Structure of a 70S Ribosome-tRNA Complex Reveals Functional Interactions and Rearrangements
Our understanding of the mechanism of protein synthesis has undergone rapid progress in recent years as a result of low-resolution X-ray and cryo-EM structures of ribosome functional complexes and… Expand
Crystal Structures of EF-G–Ribosome Complexes Trapped in Intermediate States of Translocation
Introduction: One of the most critical and complex steps of protein synthesis is the coupled translocation of mRNA and tRNAs (mRNA and tRNAs) through the ribosome, catalyzed by the guanosine… Expand