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ixabepilone

Known as: ixabepilone [Chemical/Ingredient], ixabepilone (oral), Oral Ixabepilone 
An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic… 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (2)

BMS247550IXEMPRA

Broader (2)

Epothilonesepothilone B lactam
Microtubule ProcessNCIt Antineoplastic Agent TerminologyNegative Regulation of G2 to M TransitionNegative Regulation of Microtubule Depolymerization

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Study of the Role of Anti-Cancer Molecules with Different Sizes for Decreasing Corresponding Bulk Tumor Multiple Organs or Tissues
The intermolecular forces between anti–cancer molecules such as Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin, Lobaplation… 
Highly Cited
2005
Highly Cited
2005
Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors.
PURPOSE To evaluate the safety and maximum-tolerated dose (MTD) of weekly patupilone, a natural epothilone B, in patients with… 
Review
2005
Review
2005
Recent developments in the chemical biology of epothilones.
Epothilones A and B are naturally occurring microtubule-stabilizers, which inhibit the growth of human cancer cells in vitro at… 
Highly Cited
2002
Highly Cited
2002
BINOLAM, a recoverable chiral ligand for bifunctional enantioselective catalysis: the asymmetric synthesis of cyanohydrins.
[reaction: see text] A new bifunctional catalytic system based on a monometallic aluminum complex is used for the efficient… 
Highly Cited
2002
Highly Cited
2002
Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490.
A concise modular laboratory construction of the epothilone class of promising antitumor agents has been accomplished. For the… 
Review
2001
Review
2001
Recent developments in the chemistry, biology and medicine of the epothilones.
The epothilones have occupied center stage on the scenes of total synthesis, chemical biology and medicine for the last five… 
Highly Cited
2000
Highly Cited
2000
Total syntheses of epothilones B and D.
Total syntheses of the microtubule stabilizing antitumor drugs epothilone B and D are described, starting from optically pure (S… 
Highly Cited
1999
Highly Cited
1999
A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone.
[formula: see text] Paclitaxel and epothilone represent the two major classes of antimicrotubule agents that promote tubulin… 
Highly Cited
1999
Highly Cited
1999
Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy.
Highly Cited
1996
Highly Cited
1996
Studies toward a Synthesis of Epothilone A: Stereocontrolled Assembly of the Acyl Region and Models for Macrocyclization.
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