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ixabepilone

Known as: ixabepilone [Chemical/Ingredient], ixabepilone (oral), Oral Ixabepilone 
An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic… 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (2)

BMS247550IXEMPRA

Broader (2)

Epothilonesepothilone B lactam
Microtubule ProcessNCIt Antineoplastic Agent TerminologyNegative Regulation of G2 to M TransitionNegative Regulation of Microtubule Depolymerization

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms… 
Highly Cited
2012
Highly Cited
2012
The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice
Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by insoluble deposits of hyperphosphorylated… 
Review
2009
Review
2009
Microtubule dynamics as a target in oncology.
Review
2008
Review
2008
Mechanisms and strategies to overcome chemotherapy resistance in metastatic breast cancer.
Review
2003
Review
2003
Myxobacteria: proficient producers of novel natural products with various biological activities--past and future biotechnological aspects with the focus on the genus Sorangium.
Highly Cited
2003
Highly Cited
2003
Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and sensitizes human breast cancer cells to trastuzumab, taxotere, gemcitabine, and epothilone B.
Histone deacetylase inhibitors induce hyperacetylation of the amino-terminal lysine residues of the core nucleosomal histones… 
Highly Cited
2002
Highly Cited
2002
The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to paclitaxel and epothilones, and may not require its epoxide moiety for activity.
Laulimalide is a cytotoxic natural product that stabilizes microtubules. The compound enhances tubulin assembly, and laulimalide… 
Highly Cited
2002
Highly Cited
2002
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs.
Although microtubule interacting agents inhibit spindle dynamics, thereby leading to a block in mitosis, we report that low… 
Highly Cited
2001
Highly Cited
2001
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
BMS-247550, a novel epothilone derivative, is being developed by Bristol-Myers Squibb Company (BMS) as an anticancer agent for… 
Highly Cited
1997
Highly Cited
1997
Synthesis of epothilones A and B in solid and solution phase
Epothilones A and B, two compounds that have been recently isolated1 from myxobacterium Sorangium cellulosum strain 90, have… 
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