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ixabepilone

Known as: ixabepilone [Chemical/Ingredient], ixabepilone (oral), Oral Ixabepilone 
An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic… 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (2)

BMS247550IXEMPRA

Broader (2)

Epothilonesepothilone B lactam
Microtubule ProcessNCIt Antineoplastic Agent TerminologyNegative Regulation of G2 to M TransitionNegative Regulation of Microtubule Depolymerization

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Study of the Role of Anti-Cancer Molecules with Different Sizes for Decreasing Corresponding Bulk Tumor Multiple Organs or Tissues
The intermolecular forces between anti–cancer molecules such as Cisplatin, Carboplatin, Oxaliplatin, Nedaplatin, Lobaplation… 
Highly Cited
2007
Highly Cited
2007
Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes.
PURPOSE Ixabepilone is an epothilone B analog that binds to microtubules and results in microtubule stabilization and mitotic… 
Highly Cited
2007
Highly Cited
2007
Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas.
PURPOSE To establish the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), safety, pharmacokinetics, and… 
Highly Cited
2005
Highly Cited
2005
Phase I dose-finding study of weekly single-agent patupilone in patients with advanced solid tumors.
PURPOSE To evaluate the safety and maximum-tolerated dose (MTD) of weekly patupilone, a natural epothilone B, in patients with… 
Highly Cited
2002
Highly Cited
2002
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study.
The primary aims of this study were to evaluate the timecourse and dose response of microtubule bundle formationin peripheral… 
Highly Cited
2002
Highly Cited
2002
BINOLAM, a recoverable chiral ligand for bifunctional enantioselective catalysis: the asymmetric synthesis of cyanohydrins.
[reaction: see text] A new bifunctional catalytic system based on a monometallic aluminum complex is used for the efficient… 
Review
2001
Review
2001
Recent developments in the chemistry, biology and medicine of the epothilones.
The epothilones have occupied center stage on the scenes of total synthesis, chemical biology and medicine for the last five… 
Highly Cited
2000
Highly Cited
2000
Total syntheses of epothilones B and D.
Total syntheses of the microtubule stabilizing antitumor drugs epothilone B and D are described, starting from optically pure (S… 
Highly Cited
1999
Highly Cited
1999
A unified and quantitative receptor model for the microtubule binding of paclitaxel and epothilone.
[formula: see text] Paclitaxel and epothilone represent the two major classes of antimicrotubule agents that promote tubulin… 
Highly Cited
1999
Highly Cited
1999
Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy.
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