epothilone B lactam

Known as: Epothilone B Analog, Epothilone B Analogue 
Analogues of epothilone B exhibiting antineoplastic activity. Epothilone B analogues bind to tubulin and promote tubulin polymerization and… (More)
National Institutes of Health

Papers overview

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2011
2011
Tau, a protein that is enriched in neurons of the central nervous system (CNS), is thought to play a critical role in the… (More)
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Highly Cited
2010
Highly Cited
2010
Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary… (More)
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2010
2010
Cisplatin, paclitaxel and bortezomib belong to some of the most effective families of chemotherapy drugs for solid and… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE There is a need for new agents to treat metastatic breast cancer (MBC) in patients for whom anthracycline therapy has… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Ixabepilone (BMS-247550) is an epothilone analog that optimizes the properties of naturally occurring epothilone B… (More)
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Highly Cited
2007
Highly Cited
2007
PURPOSE Ixabepilone is an epothilone B analog that binds to microtubules and results in microtubule stabilization and mitotic… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Ixabepilone (BMS-247550) is an epothilone B analog that stabilizes microtubules and has antitumor activity in taxane… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE The epothilones are a new class of tubulin-polymerizing agents with activity in taxane-sensitive and resistant tumor… (More)
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Highly Cited
2004
Highly Cited
2004
Microtubule-damaging agents (MDA) are potent antineoplastic drugs that are widely used in clinical treatment for a variety of… (More)
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