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epothilone B lactam

Known as: Epothilone B Analog, Epothilone B Analogue 
Analogues of epothilone B exhibiting antineoplastic activity. Epothilone B analogues bind to tubulin and promote tubulin polymerization and… 
National Institutes of Health

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Related topics

3 relations
Microtubule ProcessNegative Regulation of Microtubule Depolymerization

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ixabepilone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Stereoselective Synthesis of Trisubstituted Ole fi nic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design , Synthesis , and Biological Evaluation of Potent Antitumor Agents
The synthesis and biological evaluation of a series of 12,13-aziridinyl epothilone B analogues is described. These compounds were… 
2017
2017
Crafting of Neuroprotective Octapeptide from Taxol-Binding Pocket of β-Tubulin.
Microtubules play a crucial role in maintaining the shape and function of neurons. During progression of Alzheimer's disease (AD… 
2008
2008
The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: A First in Class Epothilone B Analogue in Late-Phase Clinical Development
Purpose: To determine if ixabepilone is a substrate for cytochrome P450 3A4 (CYP3A4) and if its metabolism by this cytochrome is… 
2006
2006
Final efficacy results of a phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline.
10511 Background: Ixabepilone is an epothilone B analog that has demonstrated efficacy in taxane-sensitive and taxane-resistant… 
2005
2005
Phase II trial of KOS-862 (epothilone D) in anthracycline and taxane pretreated metastatic breast cancer
778 Background: KOS-862 (K) is genetically-produced epothilone D, a naturally occurring macrolide. K has preclinical activity in… 
2005
2005
Evaluation of epothilone B analog in advanced soft tissue sarcoma: a phase II study of the phase II consortium.
PURPOSE Epothilones are a new class of nontaxane tubulin polymerization agents that have activity in taxane-resistant tumors… 
2005
2005
The epothilone dilemma.
Because of their potent antitumor activity, drugs targeting microtubules are among the most commonly prescribed anticancer agents… 
2004
2004
A phase II study of epothilone B analog (EpoB)-BMS 247550 (NSC#710428) in stage IV malignant melanoma (MM).
7542 Background: EpoB is a new non-taxane microtubule binding agent that leads to mitotic arrest. EpoB demonstrated activity in… 
Highly Cited
2002
Highly Cited
2002
A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus.
A new epothilone, 10,11-didehydroepothilone D (5), was isolated from a strain of the heterologous host Myxococcus xanthus… 
1999
1999
Epothilone A-D and their thiazole-modified analogs as novel anticancer agents
Abstract 
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