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epothilone B lactam

Known as: Epothilone B Analog, Epothilone B Analogue 
Analogues of epothilone B exhibiting antineoplastic activity. Epothilone B analogues bind to tubulin and promote tubulin polymerization and… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary… 
Review
2009
Review
2009
Highly Cited
2007
Highly Cited
2007
PURPOSE Ixabepilone (BMS-247550) is an epothilone analog that optimizes the properties of naturally occurring epothilone B… 
Highly Cited
2007
Highly Cited
2007
PURPOSE There is a need for new agents to treat metastatic breast cancer (MBC) in patients for whom anthracycline therapy has… 
Highly Cited
2005
Highly Cited
2005
  • J. LowS. Wedam S. Swain
  • Journal of clinical oncology : official journal…
  • 2005
  • Corpus ID: 10854789
PURPOSE Ixabepilone (BMS-247550) is an epothilone B analog that stabilizes microtubules and has antitumor activity in taxane… 
Highly Cited
2005
Highly Cited
2005
PURPOSE The epothilones are a new class of tubulin-polymerizing agents with activity in taxane-sensitive and resistant tumor… 
Highly Cited
2005
Highly Cited
2005
PURPOSE To evaluate the antitumor activity and safety of the epothilone B analog, ixabepilone, with or without estramustine… 
Review
2003
Review
2003
  • K. Altmann
  • Mini-Reviews in Medical Chemistry
  • 2003
  • Corpus ID: 24946792
Epothilones are naturally occurring 16-membered macrolides with the ability to promote tubulin polymerization in vitro and to…