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epothilone B lactam

Known as: Epothilone B Analog, Epothilone B Analogue 
Analogues of epothilone B exhibiting antineoplastic activity. Epothilone B analogues bind to tubulin and promote tubulin polymerization and… 
National Institutes of Health

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Related topics

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Microtubule ProcessNegative Regulation of Microtubule Depolymerization

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ixabepilone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Stereoselective Synthesis of Trisubstituted Ole fi nic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design , Synthesis , and Biological Evaluation of Potent Antitumor Agents
The synthesis and biological evaluation of a series of 12,13-aziridinyl epothilone B analogues is described. These compounds were… 
2008
2008
The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone: A First in Class Epothilone B Analogue in Late-Phase Clinical Development
Purpose: To determine if ixabepilone is a substrate for cytochrome P450 3A4 (CYP3A4) and if its metabolism by this cytochrome is… 
2006
2006
Final efficacy results of a phase I/II trial of ixabepilone in combination with capecitabine in patients with metastatic breast cancer (MBC) previously treated with a taxane and an anthracycline.
10511 Background: Ixabepilone is an epothilone B analog that has demonstrated efficacy in taxane-sensitive and taxane-resistant… 
2005
2005
Preclinical pharmacokinetics and oral bioavailability of BMS-310705, a novel epothilone B analog
PurposeBMS-310705, a novel semisynthetic derivative of epothilone B, is a tubulin-polymerization agent currently in phase I… 
2005
2005
A phase II study of KOS-862 (epothilone D) as second-line therapy in non-small cell lung cancer
7127 Background: KOS-862 is an epothilone produced by recombinant DNA technology. Epothilones act as tubulin stabilizing agents… 
2005
2005
Phase II trial of KOS-862 (epothilone D) in anthracycline and taxane pretreated metastatic breast cancer
778 Background: KOS-862 (K) is genetically-produced epothilone D, a naturally occurring macrolide. K has preclinical activity in… 
2004
2004
A phase II study of epothilone B analog (EpoB)-BMS 247550 (NSC#710428) in stage IV malignant melanoma (MM).
7542 Background: EpoB is a new non-taxane microtubule binding agent that leads to mitotic arrest. EpoB demonstrated activity in… 
2002
2002
Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures.
The introduction of the epothilone polyketide synthase (PKS) into Myxococcus xanthus has enabled the heterologous production of… 
2002
2002
Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series.
A convergent ring-closing metathesis strategy has been employed for the highly concise syntheses of 10,11-dehydro-13,14-[17… 
1999
1999
Epothilone A-D and their thiazole-modified analogs as novel anticancer agents
Abstract 
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