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epothilone B lactam

Known as: Epothilone B Analog, Epothilone B Analogue 
Analogues of epothilone B exhibiting antineoplastic activity. Epothilone B analogues bind to tubulin and promote tubulin polymerization and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Neurons in the brains of those with Alzheimer's disease (AD) and many frontotemporal dementias (FTDs) contain neurofibrillary… Expand
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Review
2009
Review
2009
Drugs that affect microtubule dynamics, including the taxanes and vinca alkaloids, have been a mainstay in the treatment of… Expand
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Highly Cited
2007
Highly Cited
2007
PURPOSE Ixabepilone (BMS-247550) is an epothilone analog that optimizes the properties of naturally occurring epothilone B… Expand
Highly Cited
2007
Highly Cited
2007
PURPOSE There is a need for new agents to treat metastatic breast cancer (MBC) in patients for whom anthracycline therapy has… Expand
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Highly Cited
2005
Highly Cited
2005
  • J. Low, S. Wedam, +8 authors S. Swain
  • Journal of clinical oncology : official journal…
  • 2005
  • Corpus ID: 10854789
PURPOSE Ixabepilone (BMS-247550) is an epothilone B analog that stabilizes microtubules and has antitumor activity in taxane… Expand
Highly Cited
2005
Highly Cited
2005
PURPOSE The epothilones are a new class of tubulin-polymerizing agents with activity in taxane-sensitive and resistant tumor… Expand
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Highly Cited
2005
Highly Cited
2005
PURPOSE To evaluate the antitumor activity and safety of the epothilone B analog, ixabepilone, with or without estramustine… Expand
Highly Cited
2003
Highly Cited
2003
PURPOSE The epothilones are a novel class of nontaxane microtubule-stabilizing agents. BMS-247550 is a semisynthetic analog of… Expand
Highly Cited
2003
Highly Cited
2003
BACKGROUND Several trials have demonstrated that the response proportions to microtubule agents in patients with prostate cancer… Expand
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Highly Cited
2000
Highly Cited
2000
The epothilone biosynthetic gene cluster was isolated from Sorangium cellulosum strain SMP44. The gene cluster contains seven… Expand