ivabradine

Known as: 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one, Ivabradin, 7,8-dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND An elevated heart rate is an established marker of cardiovascular risk. Previous analyses have suggested that… (More)
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Highly Cited
2012
Highly Cited
2012
OBJECTIVES This study used the SHIFT (Systolic Heart failure treatment with the I(f) inhibitor ivabradine Trial) database to… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Chronic heart failure is associated with high mortality and morbidity. Raised resting heart rate is a risk factor for… (More)
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Highly Cited
2009
Highly Cited
2009
AIMS To evaluate the anti-anginal and anti-ischaemic efficacy of the selective I(f) current inhibitor ivabradine in patients with… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Ivabradine specifically inhibits the I(f) current in the sinoatrial node to lower heart rate, without affecting other… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Elevated heart rate is associated with increased cardiovascular morbidity. We hypothesized that selective heart rate… (More)
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Highly Cited
2005
Highly Cited
2005
AIMS Ivabradine, a new I(f) inhibitor which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart… (More)
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Review
2004
Review
2004
Resting heart rate is associated with cardiovascular and all-cause mortality, and the mortality benefit of some cardiovascular… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Heart rate reduction (HRR) improves left ventricular (LV) filling, increases myocardial O2 supply, and reduces… (More)
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Highly Cited
2003
Highly Cited
2003
Background—Heart rate reduction should benefit patients with chronic stable angina by improving myocardial perfusion and reducing… (More)
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