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ivabradine

Known as: 3-[3-({[(7S)-3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]methyl}(methyl)amino)propyl]-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one, Ivabradin, 7,8-dimethoxy-3-(3-(((4,5-dimethoxybenzocyclobutan-1-yl)methyl)methylamino)propyl)-1,3,4,5-tetrahydro-2H-benzazepin-2-one 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

BenzazepinesCardiovascular Agents

Narrower (3)

CorlanorS 16257ivabradine hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Inhibition of JNK and p38 MAPK‐mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin‐induced diabetic cardiomyopathy
Inflammation plays a critical role in the development of diabetic cardiomyopathy (DCM), which has been identified as a major… 
Highly Cited
2015
Highly Cited
2015
Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential
Highly Cited
2014
Highly Cited
2014
Inflammatory and neuropathic pain are rapidly suppressed by peripheral block of hyperpolarisation-activated cyclic nucleotide-gated ion channels
Highly Cited
2014
Highly Cited
2014
Efficacy and safety of ivabradine in patients with chronic systolic heart failure according to blood pressure level in SHIFT
Low systolic blood pressure (SBP) is associated with poor outcomes in heart failure and complicates management. In a post hoc… 
Highly Cited
2013
Highly Cited
2013
Clinical profiles and outcomes in patients with chronic heart failure and chronic obstructive pulmonary disease: an efficacy and safety analysis of SHIFT study.
Highly Cited
2012
Highly Cited
2012
An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation
•  Computational models of the electrical activity of sinoatrial cells (SANCs) have been proposed to gain a deeper understanding… 
Highly Cited
2008
Highly Cited
2008
Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction.
AIMS Effects of the bradycardic agent ivabradine on regional blood flow, contractile function, and infarct size were studied in a… 
Highly Cited
2008
Highly Cited
2008
Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice
High resting heart rate is a predictor for total and cardiovascular mortality independent of other risk factors in patients with… 
Review
2006
Review
2006
Ivabradine – the first selective sinus node If channel inhibitor in the treatment of stable angina
Heart rate, a major determinant of angina in coronary disease, is also an important predictor of cardiovascular mortality… 
Highly Cited
2004
Highly Cited
2004
Heart rate reduction during exercise-induced myocardial ischaemia and stunning.
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