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Human Pathophysiological Adaptations to the Space Environment
TLDR
The main stress factors encountered in space and their impact on the human body are reviewed and the possible lessons learned with space exploration in reference to human health on Earth are discussed.
Cas9/sgRNA selective targeting of the P23H Rhodopsin mutant allele for treating retinitis pigmentosa by intravitreal AAV9.PHP.B-based delivery
TLDR
A CRISPR/Cas9 strategy to specifically inactivate the P23H RHO mutant, while preserving the WT allele in vitro is validated and represents an unprecedented tool for treating RP and more broadly dominant genetic human disorders affecting the eye, as well as other tissues.
Properties and functional roles of hyperpolarization‐gated currents in guinea‐pig retinal rods
TLDR
Bandpass filtering and amplification of rod signals, associated with Ih and Ikx gating by membrane hyperpolarization, are strategically located to extend, beyond the limits imposed by the slow phototransductive cascade, the temporal resolution of signals spreading to the rod synapse.
Cellular mechanisms underlying the pharmacological induction of phosphenes
TLDR
The purpose of the present paper is to outline and discuss the features of the visual system and the pharmacological conditions relevant to phosphene perception.
Selective Hcn1 channels inhibition by ivabradine in mouse rod photoreceptors.
TLDR
Phosphenes perception in response to abrupt changes in luminance, which has been transiently reported in a dose-dependent way by few patients treated with ivabradine, was consistent with Hcn1 inhibition in rods.
Adult Human Müller Glia Cells Are a Highly Efficient Source of Rod Photoreceptors
TLDR
Conditions by which human MGCs adopt a rod photoreceptor commitment with a surprising efficiency are described, which provide evidence that Müller glia retains an unpredicted plasticity and multipotent potential into adulthood, and it is therefore a promising source of novel therapeutic applications in retinal repair.
Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors
TLDR
The homomeric nature of HCN1 channels in rods is compatible with the observation that cAMP induces a small shift in the half‐activation voltage of Ih, and may reflect the need to protect the first step in the processing of visual signals from changes in cAMP turnover.
High-Pass Filtering of Input Signals by the Ih Current in a Non-Spiking Neuron, the Retinal Rod Bipolar Cell
TLDR
The functional properties conferred by Ih onto RBCs may contribute to shape the retina's light response and explain the visual side effects of HCN inhibitors.
TMEM16A is associated with voltage-gated calcium channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit
TLDR
Two experiments show association between TMEM16A and the α1 subunit of VGCC, which allows optimal function of the photoreceptor synaptic terminal under physiological conditions, but also makes TMEM 16A channels susceptible to changes occurring to calcium channels.
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