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isofagomine

Known as: 5-hydroxymethyl-3,4-piperidinediol, iso-fagomine 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

4-epi-isofagomine

Broader (1)

Imino Pyranoses

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Determination of d-fagomine in buckwheat and mulberry by cation exchange HPLC/ESI–Q-MS
Abstractd-Fagomine is an iminosugar first found in buckwheat (Fagopyrum esculentum Moench) which if used as a dietary supplement… 
2012
2012
Asymmetric synthesis of polyhydroxylated N-alkoxypiperidines by ring-closing double reductive amination: facile preparation of isofagomine and analogues.
A de novo synthesis of novel polyhydroxylated N-alkoxypiperidines based on the ring-closing double reductive amination of 1,5… 
Highly Cited
2011
Highly Cited
2011
Ex Vivo and in Vivo Effects of Isofagomine on Acid β-Glucosidase Variants and Substrate Levels in Gaucher Disease*
Background: “Chaperones” may enhance mutant enzyme activities, but therapeutic levels have not been shown in vivo. Results: A… 
Highly Cited
2011
Highly Cited
2011
Isofagomine In Vivo Effects in a Neuronopathic Gaucher Disease Mouse
The pharmacological chaperone, isofagomine (IFG), enhances acid β-glucosidase (GCase) function by altering folding, trafficking… 
Highly Cited
2009
Highly Cited
2009
Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability.
Human lysosomal enzymes acid-beta-glucosidase (GCase) and acid-alpha-galactosidase (alpha-Gal A) hydrolyze the sphingolipids… 
Highly Cited
2008
Highly Cited
2008
Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β‐Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry
Point mutations in β‐glucocerebrosidase (GCase) can result in a deficiency of both GCase activity and protein in lysosomes… 
Highly Cited
2005
Highly Cited
2005
Astrocyte glycogen metabolism is required for neural activity during aglycemia or intense stimulation in mouse white matter
We tested the hypothesis that inhibiting glycogen degradation accelerates compound action potential (CAP) failure in mouse optic… 
2003
2003
Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting beta-glucosidases.
A cellobio-derived isofagomine glycosidase inhibitor (Ki approximately 400 nM) displays an unusual distorted 2,5B (boat… 
2001
2001
Selective fowler reductions: asymmetric total syntheses of isofagomine and other 1-azasugars from methyl nicotinate.
[figure: see text] An efficient, high-yielding strategy has been developed for the asymmetric synthesis of 1-N-iminosugars (1… 
2001
2001
Efficient synthesis of isofagomine and noeuromycin.
Starting from D-arabinose the synthesis of the very strong glycosidase inhibitors isofagomine (2) and noeuromycin (3) was… 
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