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involucrin

Known as: Benzoic acid, 3,4,5-trimethoxy-, 4-(acetyloxy)-6,10-dimethyl-3-(1-methylethyl)-11-oxabicyclo(8.1.0)undec-6-en-2-yl ester 
Involucrin (585 aa, ~68 kDa) is encoded by the human IVL gene. This protein plays a role in the keratinization of stratified squamous epithelia.
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

IVL geneProtein Precursors
KeratinStratified squamous epitheliumStructural ProteinStructural gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Clinical and immunohistochemical evaluation of psoriatic plaques treated with topical 5‐aminolaevulinic acid photodynamic therapy
Background/purpose: The aims of this study were to investigate the clinical and immunohistochemical events of psoriatic plaques… 
2003
2003
Hypoxia and differentiation in squamous cell carcinomas of the uterine cervix: pimonidazole and involucrin.
PURPOSE Pimonidazole binding (hypoxia) and involucrin expression (differentiation) overlap extensively in squamous cell… 
Highly Cited
2000
Highly Cited
2000
Targeted Ablation of the Murine Involucrin Gene
Involucrin is synthesized in abundance during terminal differentiation of keratinocytes. Involucrin is a substrate for… 
Highly Cited
2000
Highly Cited
2000
Expression of involucrin in normal, hyperproliferative and neoplastic mouse keratinocytes
Abstract: Involucrin is a protein precursor of the epidermal cornified envelope. Although expression of the human protein has… 
1999
1999
High-cell-density phorbol ester and retinoic acid upregulate involucrin and downregulate suprabasal keratin 10 in autocrine cultures of human epidermal keratinocytes.
Autocrine growth of human epidermal keratinocytes is initiated in subconfluent cell cultures in the absence of exogenous growth… 
Highly Cited
1993
Highly Cited
1993
Analysis of the 5'-upstream promoter region of human involucrin gene: activation by 12-O-tetradecanoylphorbol-13-acetate.
Involucrin is one of the precursor proteins of keratinocyte cornified envelope. Although the formation of the cornified envelope… 
Highly Cited
1991
Highly Cited
1991
Reconstruction of human epidermis on de-epidermized dermis: Expression of differentiation-specific protein markers and lipid composition.
1989
1989
Heterogeneity of keratin expression in epithelial tumor cells of adenolymphoma in paraffin sections.
Highly Cited
1986
Highly Cited
1986
Wound healing of human skin transplanted onto the nude mouse. I. An immunohistological study of the reepithelialization process.
Highly Cited
1983
Highly Cited
1983
Modulation of involucrin and envelope competence in human keratinocytes by hydrocortisone, retinyl acetate, and growth arrest.
Involucrin accumulation and ionophore-assisted envelope formation, markers of keratinocyte differentiation, were found to be… 
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