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Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis
Summary Lrig1 is a marker of human interfollicular epidermal stem cells and helps maintain stem cell quiescence. We show that, in mouse epidermis, Lrig1 defines the hair follicle junctional zoneExpand
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Stem cell patterning and fate in human epidermis
Within human epidermis there are two types of proliferating keratinocyte: stem cells, which have high proliferative potential, and transit-amplifying cells, which are destined to undergo terminalExpand
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Role of integrins in regulating epidermal adhesion, growth and differentiation
  • F. Watt
  • Biology, Medicine
  • The EMBO journal
  • 1 August 2002
Mammalian epidermis is renewed throughout life by proliferation of a multipotential stem cell population and terminal differentiation of stem cell progeny. In recent years, extracellular matrixExpand
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Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression
The epidermis is believed to contain two types of proliferating cells: stem cells and cells with a lower capacity for self-renewal and higher probability of undergoing terminal differentiationExpand
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Distinct fibroblast lineages determine dermal architecture in skin development and repair
Fibroblasts are the major mesenchymal cell type in connective tissue and deposit the collagen and elastic fibres of the extracellular matrix (ECM). Even within a single tissue, fibroblasts exhibitExpand
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Autophagy mediates the mitotic senescence transition.
As a stress response, senescence is a dynamic process involving multiple effector mechanisms whose combination determines the phenotypic quality. Here we identify autophagy as a new effectorExpand
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Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
The dermal papilla comprises the specialised mesenchymal cells at the base of the hair follicle. Communication between dermal papilla cells and the overlying epithelium is essential forExpand
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Stem Cell Depletion Through Epidermal Deletion of Rac1
Mammalian epidermis is maintained by self-renewal of stem cells, but the underlying mechanisms are unknown. Deletion of Rac1, a Rho guanosine triphosphatase, in adult mouse epidermis stimulated stemExpand
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c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny
BACKGROUND The epidermis is maintained throughout adult life by pluripotential stem cells that give rise, via daughter cells of restricted self-renewal capacity and high differentiation probabilityExpand
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Lrig1 controls intestinal stem cell homeostasis by negative regulation of ErbB signalling
Maintenance of adult tissues is carried out by stem cells and is sustained throughout life in a highly ordered manner. Homeostasis within the stem-cell compartment is governed by positive- andExpand
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