• Publications
  • Influence
A framework for advancing our understanding of cancer-associated fibroblasts
TLDR
This Consensus Statement issues a call to action for all cancer researchers to standardize assays and report metadata in studies of cancer-associated fibroblasts to advance the understanding of this important cell type in the tumour microenvironment.
Distinct fibroblast lineages determine dermal architecture in skin development and repair
TLDR
It is shown, using transplantation assays and lineage tracing in mice, that the fibroblasts of skin connective tissue arise from two distinct lineages, which explains why wounding is linked to formation of ECM-rich scar tissue that lacks hair follicles.
Role of integrins in regulating epidermal adhesion, growth and differentiation
  • F. Watt
  • Biology
    The EMBO journal
  • 1 August 2002
TLDR
What is known about the expression and function of epidermal integrins is summarized, the challenges for future research are highlighted, and there is good evidence that specificintegrins can contribute positively or negatively to pathogenesis.
Autophagy mediates the mitotic senescence transition.
TLDR
The data suggest that autophagy, and its consequent protein turnover, mediate the acquisition of the senescence phenotype.
Sox2-positive dermal papilla cells specify hair follicle type in mammalian epidermis
TLDR
A previously unrecognised heterogeneity in dermal papilla cells is demonstrated and it is shown that Sox2-positive cells specify particular hair follicle types.
Stem Cell Depletion Through Epidermal Deletion of Rac1
TLDR
It is proposed that Rac and Myc represent a global stem cell regulatory axis and a pleiotropic regulator of cell adhesion and the cytoskeleton plays a critical role in controlling exit from the stem cell niche.
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