Targeted Ablation of the Murine Involucrin Gene

@article{Djian2000TargetedAO,
  title={Targeted Ablation of the Murine Involucrin Gene},
  author={Philippe Djian and Karen Easley and Howard A. Green},
  journal={The Journal of Cell Biology},
  year={2000},
  volume={151},
  pages={381 - 388}
}
Involucrin is synthesized in abundance during terminal differentiation of keratinocytes. Involucrin is a substrate for transglutaminase and one of the precursors of the cross-linked envelopes present in the corneocytes of the epidermis and other stratified squamous epithelia. These envelopes make an important contribution to the physical resistance of the epidermis. We have generated mice lacking involucrin from embryonic stem cells whose involucrin gene had been ablated by homologous… CONTINUE READING

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These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
EpidermisIs normal tissue origin of diseaseSquamous cell carcinoma of skin
Involucrin is a substrate for transglutaminase and one of the precursors of the cross - linked envelopes present in the corneocytes of the epidermis and other stratified squamous epithelia .
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
Hair follicle structureConstitutional part ofEpidermis
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
These mice developed normally , possessed apparently normal epidermis and hair follicles , and made cornified envelopes that could not be distinguished from those of wild - type mice .
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