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intetumumab

Known as: monoclonal antibody CNTO 95, Human Monoclonal CNTO 95 gamma1 heavy chain (222-215')-disulfide with Human Monoclonal CNTO 95 kappa light chain dimer (228-228'':231-231'')-bisdisulfide, CNTO-95 
A pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and alpha-v beta-6 integrins with… Expand
National Institutes of Health

Papers overview

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2013
2013
BACKGROUND Intetumumab is a fully human mAb with antiangiogenic, antitumor properties which has shown potential therapeutic… Expand
Highly Cited
2011
Highly Cited
2011
Background:αv integrins are involved in angiogenesis and melanoma tumourigenesis. Intetumumab (CNTO 95) is a fully human anti-αv… Expand
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2010
2010
We previously reported that intetumumab (CNTO 95), a fully human anti-αv integrin monoclonal antibody, is a radiosensitizer in… Expand
2008
2008
Selective targeting of up-regulated integrins on tumor cells is a novel antiangiogenesis strategy for treating solid tumors. CNTO… Expand
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Highly Cited
2007
Highly Cited
2007
Purpose: A fully human monoclonal antibody to anti–αv integrins (CNTO 95) has been shown to inhibit angiogenesis and tumor growth… Expand
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Highly Cited
2007
Highly Cited
2007
CNTO 95 is a fully human monoclonal antibody that recognizes αv integrins. Previous studies have shown that CNTO 95 exhibits both… Expand
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2007
2007
Purpose: Targeted delivery of cytotoxic agents to solid tumors through cell surface antigens can potentially reduce systemic… Expand
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2005
2005
Purpose: CNTO 95 is a fully human anti-αv integrin monoclonal antibody that inhibits macaque and rodent angiogenesis and inhibits… Expand
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Highly Cited
2004
Highly Cited
2004
Integrins of the αv family, such as αvβ3 and αvβ5, are implicated in tumor‐induced angiogenesis; but their role in tumor growth… Expand
2004
2004
3119 Background: Integrins of the αv family are implicated in tumor angiogenesis and growth. CNTO 95 is a fully human mAb that… Expand