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intetumumab

Known as: monoclonal antibody CNTO 95, Human Monoclonal CNTO 95 gamma1 heavy chain (222-215')-disulfide with Human Monoclonal CNTO 95 kappa light chain dimer (228-228'':231-231'')-bisdisulfide, CNTO-95 
A pan alpha-v human monoclonal antibody that recognizes alpha-v beta-1, alpha-v beta-3, alpha-v beta-5, and alpha-v beta-6 integrins with… 
National Institutes of Health

Papers overview

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2013
2013
BACKGROUND Intetumumab is a fully human mAb with antiangiogenic, antitumor properties which has shown potential therapeutic… 
Highly Cited
2011
Highly Cited
2011
Background:αv integrins are involved in angiogenesis and melanoma tumourigenesis. Intetumumab (CNTO 95) is a fully human anti-αv… 
2010
2010
We previously reported that intetumumab (CNTO 95), a fully human anti-αv integrin monoclonal antibody, is a radiosensitizer in… 
2010
2010
SummaryPurpose We evaluated the safety and efficacy of intetumumab in combination with docetaxel in patients with castrate… 
2008
2008
Selective targeting of up-regulated integrins on tumor cells is a novel antiangiogenesis strategy for treating solid tumors. CNTO… 
Highly Cited
2007
Highly Cited
2007
Purpose: A fully human monoclonal antibody to anti–αv integrins (CNTO 95) has been shown to inhibit angiogenesis and tumor growth… 
Highly Cited
2007
Highly Cited
2007
CNTO 95 is a fully human monoclonal antibody that recognizes αv integrins. Previous studies have shown that CNTO 95 exhibits both… 
2007
2007
Purpose: Targeted delivery of cytotoxic agents to solid tumors through cell surface antigens can potentially reduce systemic… 
2005
2005
Purpose: CNTO 95 is a fully human anti-αv integrin monoclonal antibody that inhibits macaque and rodent angiogenesis and inhibits… 
Highly Cited
2004
Highly Cited
2004
Integrins of the αv family, such as αvβ3 and αvβ5, are implicated in tumor‐induced angiogenesis; but their role in tumor growth…