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inostamycin

Known as: Lysocellin, 20-de(1-hydroxypropyl)-6-demethyl-2,6-diethyl-5-hydroxy-20-(1-hydroxybutyl)-, (2S,4S,5R)- 
National Institutes of Health

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Papers overview

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2012
2012
Inostamycin enhanced TRAIL-induced apoptosis through DR5 upregulation on the cell surface
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered as a possible therapeutic agent for cancer… 
Review
2010
Review
2010
Inostamycin prevents malignant phenotype of cancer: inhibition of phosphatidylinositol synthesis provides a therapeutic advantage for head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma is the sixth most common type of neoplasm worldwide, but its prognosis has not improved… 
2005
2005
Studies on the synthesis of the inostamycin natural products: a reductive aldol/reductive Claisen approach to the C10-C24 ketone fragment.
[reaction: see text] An approach to the C10-C24 ketone fragment of the inostamycin family of polyether antibiotics is described… 
2005
2005
Inostamycin suppresses vascular endothelial growth factor-stimulated growth and migration of human umbilical vein endothelial cells
Angiogenesis involves multiple steps including proliferation and migration of endothelial cells. In the present study, we… 
2003
2003
Transmembrane domain of Bcl-2 is required for inhibition of ceramide synthesis, but not cytochrome c release in the pathway of inostamycin-induced apoptosis.
1998
1998
Inhibition of Cyclin D1 Expression and Induction of Apoptosis by Inostamycin in Small Cell Lung Carcinoma Cells
Previously, we demonstrated that inostamycin, an inhibitor of phosphatidylinositol turnover, caused cell cycle arrest at the G1… 
1998
1998
Potentiation of Paclitaxel Cytotoxicity by Inostamycin in Human Small Cell Lung Carcinoma, Ms‐1 Cells
In the present study, we found that inostamycin increased the ability of paclitaxel to induce apoptosis in Ms‐1 cells. A… 
Review
1995
Review
1995
Isolation and biological activities of signal transduction inhibitors from microorganisms and plants.
1994
1994
Involvement of phosphatidylinositol synthesis in the regulation of S phase induction.
The addition of serum to quiescent normal rat kidney (NRK) cells induced phosphatidylinositol (PI) synthesis after 4 h and DNA… 
1991
1991
Long‐lasting Accumulation of Vinblastine in Inostamycin‐treated Multidrug‐resistant KB Cells
Inostamycin, a novel polyether compound, reverses multidrug resistance in KB cells. The mechanism of its action was studied by… 
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