ingliforib

Known as: 5-Chloro-N-((1S,2R)-3-((3R,4S)-3,4-dihydroxy-1-pyrrolidinyl))-2-hydroxy-3-oxo-1-(phenylmethyl)propyl-1H-indole-2-carboxamide 
A glycogen phosphorylase inhibitor with antihyperglycemic and cardioprotective activities. Ingliforib inhibits glycogen phosphorylase, the rate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2017
024619862017

Papers overview

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2016
2016
Our team had previously identified certain indolecarboxamides that represented a new chemical scaffold that showed promising anti… (More)
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2013
2013
BACKGROUND AND PURPOSE The cannabinoid receptor type 1 (CB1 ) has an allosteric binding site. The drugs ORG27569 {5-chloro-3… (More)
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2013
2013
Allosteric modulation of G-protein coupled receptors (GPCRs) represents a novel approach for fine-tuning GPCR functions. The… (More)
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2013
2013
The cannabinoid CB1 receptor is involved in complex physiological functions. The discovery of CB1 allosteric modulators generates… (More)
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2011
2011
Hyaluronic acid (HA) is the major biopolymer of the extracellular matrix and contributes significantly to cell proliferation and… (More)
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Highly Cited
2007
Highly Cited
2007
Glycogen in the brain is localized almost exclusively to astrocytes. The physiological function of this energy store has been… (More)
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2004
2004
Interventions such as glycogen depletion, which limit myocardial anaerobic glycolysis and the associated proton production, can… (More)
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2000
2000
We studied the cerebroprotective effect of SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulphonate), a… (More)
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Highly Cited
1998
Highly Cited
1998
An inhibitor of human liver glycogen phosphorylase a (HLGPa) has been identified and characterized in vitro and in vivo. This… (More)
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Highly Cited
1986
Highly Cited
1986
3S(-)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepine-3-yl)-1H-indole-2-carboxamide (L-364,718) interacted in a… (More)
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