indoximod

Known as: D-(+)-1-Methyltryptophan, D-1MT, 1-MT 
A substance being studied in the treatment of melanoma and many other types of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid… (More)

Topic mentions per year

Topic mentions per year

1981-2018
05101519812018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Although elevated activity of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) has been proposed to mediate… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Mesenchymal stem cells (MSCs) can inhibit T cell proliferation; however, the underlying mechanisms are not clear. In this study… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Indoleamine-2,3-Dioxygenase (IDO) is an immunosuppressive molecule inducible in various cells. In addition to classic IDO (IDO1… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Clinical trials have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
The induction of tolerance towards allogeneic solid organ grafts is one of the major goals in transplantation medicine… (More)
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Indoleamine 2,3-dioxygenase (IDO) is a novel immunosuppressive agent expressed in some subsets of normal and neoplastic cells… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 6
Is this relevant?
Highly Cited
2006
Highly Cited
2006
CpG-rich oligonucleotides (CpG-ODN) bind to Toll-like receptor 9 (TLR9) and are used as powerful adjuvants for vaccination. Here… (More)
Is this relevant?
2004
2004
Interactions between antigen-presenting cells and T cells can result in T cell activation or suppression. With the use of RNA… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Experimental autoimmune encephalomyelitis (EAE) is a T cell-mediated demyelinating disease of the central nervous system (CNS… (More)
Is this relevant?