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indoximod

Known as: D-(+)-1-Methyltryptophan, D-1MT, 1-MT 
A substance being studied in the treatment of melanoma and many other types of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

1-methyltryptophan
methanol-5-hydroxybenzimidazolylcobamide Co-methyltransferase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Abstract CT117: Interim analysis of the Phase 2 clinical trial of the IDO pathway inhibitor indoximod in combination with pembrolizumab for patients with advanced melanoma
Background: The indoleamine 2,3-dioxygenase (IDO) pathway is a key counter-regulatory mechanism that normally inhibits immune… 
2015
2015
Pharmacokinetics of 1-methyl-L-tryptophan after single and repeated subcutaneous application in a porcine model
Increased activity of the tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO) is associated with immunological and… 
2014
2014
A Phase I study of NLG919 for adult patients with recurrent advanced solid tumors
Meeting abstracts Clinical Trial Registration Number: [NCT02048709][1] The enzyme Indoleamine 2,3-dioxygenase (IDO1) catalyzes… 
2011
2011
Anticancer effects of imatinib via immunostimulation
Imatinib represents the quintessential example of a targeted anticancer agent that directly suppresses the activation of… 
2010
2010
Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma.
Review
2008
Review
2008
Role of homocysteine in the treatment of Parkinson's disease
The saga of harmful administration of levodopa (LD) in the treatment of Parkinson’s disease (PD) resulted from outcomes of animal… 
2006
2006
Effect of 50-Hz 1-mT magnetic field on the uterus and ovaries of rats (electron microscopy evaluation).
BACKGROUND The aim of this study was to investigate the effect of extremely low frequency magnetic fields (ELFMF) on the uterus… 
2006
2006
Indoleamine 2,3-dioxygenase (IDO) is involved in promoting the development of anterior chamber-associated immune deviation.
2004
2004
Design of a five-coordinate heme protein maquette: a spectroscopic model of deoxymyoglobin.
The substitution of 1-methyl-l-histidine for the histidine heme ligands in a de novo designed four-alpha-helix bundle scaffold… 
1966
1966
Spectrophotometric study of the acetylcholinesterase-catalyzed hydrolysis of 1-methyl-acetoxyquinolinium iodides.
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