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indoximod

Known as: D-(+)-1-Methyltryptophan, D-1MT, 1-MT 
A substance being studied in the treatment of melanoma and many other types of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Exploding interest in immunometabolism as a source of new cancer therapeutics has been driven in large part by studies of… Expand
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Highly Cited
2016
Highly Cited
2016
Purpose Indoximod is an oral inhibitor of the indoleamine 2,3-dioxygenase pathway, which causes tumor-mediated immunosuppression… Expand
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Highly Cited
2014
Highly Cited
2014
Background Indoleamine 2,3-dioxygenase (IDO) is an enzyme that tumors use to create a state of immunosuppression. Indoximod is an… Expand
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Highly Cited
2010
Highly Cited
2010
Mesenchymal stem cells (MSCs) possess potent and broad immunosuppressive capabilities, and have shown promise in clinical trials… Expand
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-catabolizing enzyme that induces immune tolerance. The purpose of the… Expand
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Highly Cited
2009
Highly Cited
2009
It has been reported that levo-1-methyl tryptophan (L-1MT) can block indoleamine-2,3-dioxygenase (IDO) expressed by human… Expand
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Highly Cited
2008
Highly Cited
2008
Clinical trials have been started with the aim of inducing tumor immunity by blocking the immunosuppressive action of indoleamine… Expand
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Highly Cited
2007
Highly Cited
2007
Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being translated to clinic for evaluation as cancer… Expand
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Highly Cited
2007
Highly Cited
2007
Indoleamine 2,3-dioxygenase (IDO) is a novel immunosuppressive agent expressed in some subsets of normal and neoplastic cells… Expand
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Highly Cited
2004
Highly Cited
2004
Organophosphates used as flame retardants, plasticisers and lubricants such as tris-(2-chloro-, 1-methyl-ethyl)-phosphate (TCPP… Expand
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