Calreticulin exposure dictates the immunogenicity of cancer cell death
- M. Obeid, A. Tesnière, G. Kroemer
- Biology, ChemistryNature Network Boston
- 2007
It is shown that anthracyclin-induced CRT translocation induces the rapid, preapoptotic translocation of calreticulin (CRT) to the cell surface and is identified as a key feature determining anticancer immune responses.
Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
- B. Routy, E. Le Chatelier, L. Zitvogel
- Medicine, BiologyScience
- 5 January 2018
It is found that primary resistance to ICIs can be attributed to abnormal gut microbiome composition, and Antibiotics inhibited the clinical benefit of ICIs in patients with advanced cancer.
Exosomes: composition, biogenesis and function
- C. Théry, L. Zitvogel, S. Amigorena
- BiologyNature reviews. Immunology
- 1 August 2002
The physical properties that define exosomes as a specific population of secreted vesicles are described, their biological effects, particularly on the immune system, are summarized, and the potential roles that secretedvesicles could have as intercellular messengers are discussed.
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
- L. Apetoh, F. Ghiringhelli, L. Zitvogel
- Biology, MedicineNature Network Boston
- 1 September 2007
A previously unrecognized pathway for the activation of tumor antigen–specific T-cell immunity that involves secretion of the high-mobility-group box 1 (HMGB1) alarmin protein by dying tumor cells and the action of HMGB1 on Toll-like receptor 4 (TLR4) expressed by dendritic cells (DCs) is described.
Immunogenic cell death in cancer therapy.
- G. Kroemer, L. Galluzzi, O. Kepp, L. Zitvogel
- Biology, MedicineAnnual Review of Immunology
- 21 March 2013
It is postulate that ICD constitutes a prominent pathway for the activation of the immune system against cancer, which in turn determines the long-term success of anticancer therapies and its subversion by pathogens.
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
- V. Gopalakrishnan, C. Spencer, J. Wargo
- Medicine, BiologyScience
- 5 January 2018
Examination of the oral and gut microbiome of melanoma patients undergoing anti-programmed cell death 1 protein (PD-1) immunotherapy suggested enhanced systemic and antitumor immunity in responding patients with a favorable gut microbiome as well as in germ-free mice receiving fecal transplants from responding patients.
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
- L. Galluzzi, I. Vitale, G. Kroemer
- BiologyCell Death and Differentiation
- 23 January 2018
An updated classification of cell death subroutines focusing on mechanistic and essential aspects of the process is proposed, and the utility of neologisms that refer to highly specialized instances of these processes are discussed.
Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
- M. Vetizou, J. Pitt, L. Zitvogel
- Biology, MedicineScience
- 27 November 2015
A key role is revealed for Bacteroidales in the immunostimulatory effects of CTLA-4 blockade, which is found to depend on distinct Bacteroides species in mice and patients.
Antigen presentation and T cell stimulation by dendritic cells.
- P. Guermonprez, J. Valladeau, L. Zitvogel, C. Théry, S. Amigorena
- BiologyAnnual Review of Immunology
- 2002
Dendritic cells take up antigens in peripheral tissues, process them into proteolytic peptides, and load these peptides onto major histocompatibility complex (MHC) class I and II molecules, thus initiating antigen-specific immune responses, or immunological tolerance.
Innate or Adaptive Immunity? The Example of Natural Killer Cells
- É. Vivier, D. Raulet, S. Ugolini
- BiologyScience
- 7 January 2011
NK cells are now recognized to express a repertoire of activating and inhibitory receptors that is calibrated to ensure self-tolerance while allowing efficacy against assaults such as viral infection and tumor development.
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