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indoxam

 
National Institutes of Health

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2 relations

Broader (2)

CarbamatesIndolizines

Papers overview

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Highly Cited
2010
Highly Cited
2010
Production of Vascular Endothelial Growth Factors from Human Lung Macrophages Induced by Group IIA and Group X Secreted Phospholipases A2
Angiogenesis and lymphangiogenesis mediated by vascular endothelial growth factors (VEGFs) are main features of chronic… Expand
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2009
2009
Lung mast cells are a source of secreted phospholipases A2.
BACKGROUND Secreted phospholipases A(2) (sPLA(2)s) are released in plasma and other biologic fluids of patients with inflammatory… Expand
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2008
2008
Secretory PLA2 inhibitor indoxam suppresses LDL modification and associated inflammatory responses in TNFα‐stimulated human endothelial cells
Secretory phospholipase A2 (sPLA2) is implicated in atherosclerosis, although the effects of specific sPLA2 inhibitors have not… Expand
Highly Cited
2005
Highly Cited
2005
Activation of Cytokine Production by Secreted Phospholipase A2 in Human Lung Macrophages Expressing the M-Type Receptor1
Secreted phospholipases A2 (sPLA2) are enzymes released in plasma and extracellular fluids during inflammatory diseases. Because… Expand
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Highly Cited
2004
Highly Cited
2004
Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues: a structure-guided study.
Structure-guided design was employed in a search for potent and selective inhibitors of mammalian secreted phospholipases A(2… Expand
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Highly Cited
2002
Highly Cited
2002
Interfacial Kinetic and Binding Properties of the Complete Set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2 *
Expression of the full set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2 (sPLA2s) in Escherichia coli… Expand
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Highly Cited
2002
Highly Cited
2002
Human group IIA secretory phospholipase A2 induces neuronal cell death via apoptosis.
Expression of group IIA secretory phospholipase A2 (sPLA2-IIA) is documented in the cerebral cortex (CTX) after ischemia… Expand
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2001
2001
Group X secretory phospholipase A(2) induces potent productions of various lipid mediators in mouse peritoneal macrophages.
We have previously shown the expression of group X secretory phospholipase A(2) (sPLA(2)-X) in mouse splenic macrophages and its… Expand
Highly Cited
2000
Highly Cited
2000
Structures, Enzymatic Properties, and Expression of Novel Human and Mouse Secretory Phospholipase A2s*
Mammalian secretory phospholipase A2s (sPLA2s) form a family of structurally related enzymes that are involved in a variety of… Expand
Highly Cited
1999
Highly Cited
1999
Suppression of murine endotoxic shock by sPLA2 inhibitor, indoxam, through group IIA sPLA2-independent mechanisms.
Endotoxic shock is a systemic inflammatory process, involving a variety of proinflammatory mediators. Two types of secretory… Expand
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