indole-3-glycerol-phosphate lyase activity

Known as: indole synthase activity, TSA, indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity 
Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate. [EC:4.1.2.8]
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Epigenetics, DNA methylation, and chromatin modifying drugs.
  • Moshe Szyf
  • Annual review of pharmacology and toxicology
  • 2009
Evidence is emerging that several diseases and behavioral pathologies result from defects in gene function. The best-studied… (More)
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Highly Cited
2005
Highly Cited
2005
Regulation of LSD1 histone demethylase activity by its associated factors.
LSD1 is a recently identified human lysine (K)-specific histone demethylase. LSD1 is associated with HDAC1/2; CoREST, a SANT… (More)
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Highly Cited
2005
Highly Cited
2005
The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation.
Nuclear-envelope proteins have been implicated in diverse and fundamental cell functions, among them transcriptional regulation… (More)
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Highly Cited
2005
Highly Cited
2005
Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.
In this study, we have evaluated the cytotoxic effect of combining two HDAC inhibitors, SAHA and TSA, with TRAIL in human… (More)
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Highly Cited
2005
Highly Cited
2005
Histone deacetylase inhibitors promote osteoblast maturation.
UNLABELLED HDIs are potential therapeutic agents for cancer and neurological diseases because of their abilities to alter gene… (More)
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Highly Cited
2002
Highly Cited
2002
Oxidative stress and TNF-alpha induce histone acetylation and NF-kappaB/AP-1 activation in alveolar epithelial cells: potential mechanism in gene transcription in lung inflammation.
Oxidants and inflammatory mediators such as tumour necrosis factor-alpha (TNF-alpha) activate nuclear factor kappa B (NF-kappaB… (More)
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Highly Cited
2002
Highly Cited
2002
Precipitous release of methyl-CpG binding protein 2 and histone deacetylase 1 from the methylated human multidrug resistance gene (MDR1) on activation.
Overexpression of the human multidrug resistance gene 1 (MDR1) is a negative prognostic factor in leukemia. Despite intense… (More)
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Highly Cited
2000
Highly Cited
2000
An herbivore elicitor activates the gene for indole emission in maize.
Maize and a variety of other plant species release volatile compounds in response to herbivore attack that serve as chemical cues… (More)
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Highly Cited
2000
Highly Cited
2000
Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms.
Stra13 is a transcriptional repressor related within its basic helix-loop-helix domain with the Drosophila Hairy, Enhancer of… (More)
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Highly Cited
1997
Highly Cited
1997
Transient Inhibition of Histone Deacetylation Alters the Structural and Functional Imprint at Fission Yeast Centromeres
Histone acetylation may act to mark and maintain transcriptionally active or inactive chromosomal domains through the cell cycle… (More)
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