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indole-3-glycerol-phosphate lyase activity

Known as: indole synthase activity, TSA, indole-3-glycerolphosphate D-glyceraldehyde-3-phosphate-lyase activity 
Catalysis of the reaction: (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = indole + D-glyceraldehyde 3-phosphate. [EC:4.1.2.8]
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Interactive effects of HDAC inhibitors and TRAIL on apoptosis are associated with changes in mitochondrial functions and expressions of cell cycle regulatory genes in multiple myeloma.
In this study, we have evaluated the cytotoxic effect of combining two HDAC inhibitors, SAHA and TSA, with TRAIL in human… 
Highly Cited
2005
Highly Cited
2005
Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells
In LNCaP prostate cancer cells CG-1521, a new inhibitor of histone deacetylases, alters the acetylation of p53 in a site-specific… 
Highly Cited
2002
Highly Cited
2002
Precipitous Release of Methyl-CpG Binding Protein 2 and Histone Deacetylase 1 from the Methylated Human Multidrug Resistance Gene (MDR1) on Activation
ABSTRACT Overexpression of the human multidrug resistance gene 1 (MDR1) is a negative prognostic factor in leukemia. Despite… 
Highly Cited
2002
Highly Cited
2002
Inhibitors of Histone Deacetylase and DNA Methyltransferase Synergistically Activate the Methylated Metallothionein I Promoter by Activating the Transcription Factor MTF-1 and Forming an Open…
ABSTRACT Inhibitors of DNA methyltransferase (Dnmt) and histone deacetylases (HDAC) synergistically activate the methylated… 
Highly Cited
2000
Highly Cited
2000
Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms.
Stra13 is a transcriptional repressor related within its basic helix-loop-helix domain with the Drosophila Hairy, Enhancer of… 
Highly Cited
1997
Highly Cited
1997
Transient Inhibition of Histone Deacetylation Alters the Structural and Functional Imprint at Fission Yeast Centromeres
Highly Cited
1997
Highly Cited
1997
Antitumor efficacy of adenocarcinoma cells engineered to produce interleukin 12 (IL-12) or other cytokines compared with exogenous IL-12.
BACKGROUND Numerous animal model studies have examined the ability of genetically engineered tumor cells to release cytokines and… 
Highly Cited
1992
Highly Cited
1992
Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin.
Lysophosphatidic acid (LPA) is a naturally occurring phospholipid with growth-factor-like activities [van Corven, Groenink… 
Highly Cited
1977
Highly Cited
1977
Characterization of the Autoregulation of Simian Virus 40 Gene A
Cells infected by tsA mutants of simian virus 40 (SV40) overproduce early RNA. Overproduction results from failure of the… 
Highly Cited
1977
Highly Cited
1977
Temperature-sensitive growth regulation in one type of transformed rat cells induced by the tsa mutant of polyoma virus
A fibroblast line of the 3T3 type with a low saturation density was established from Fisher rat embryo cells. After infection… 
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