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indicine-N-oxide

Known as: Butanoic Acid, 2,3-Dihydroxy-2-(1-methylethyl)- (2,3,5, 7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) Methyl Ester, N-Oxide,(1R-(1alpha,7(2R*,3S*),7a-beta))-(9CI), 2,3-dihydroxy-2-(1-methylethyl) butanoic acid (2,3,5,7a-tetrahydro-1-hydroxy- 1H-pyrrolizin-7-yl)methyl ester N-oxide, INDI 
A natural pyrrolizidine alkaloid with antineoplastic properties. Indicine-N-oxide alkylates and crosslinks DNA. (NCI04)
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antineoplastic Agents, PhytogenicPyrrolizidine Alkaloids
NCIt Antineoplastic Agent Terminology

Narrower (1)

NSC 132319

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Battle of the sexes may set the brain
A tug-of-war between the mother's and father's genes in the developing brain could explain a spectrum of mental disorders from… 
Highly Cited
2006
Highly Cited
2006
Fire in eastern oak forests: delivering science to land managers
Contains 20 papers and 36 poster abstracts presented at a conference on fire in oak forests of the Eastern United States that was… 
Highly Cited
1996
Highly Cited
1996
Interference between Bulk and Surface Photoemission Transitions in Ag(111).
The direct-transition photoemission peak from the sp valence band of Ag(111) shows a pronounced asymmetry. The emission intensity… 
Highly Cited
1995
Highly Cited
1995
A Novel Method for Rapid Micropropagation of Pineapple
A novel micropropagation method for pineapple (Ananas comosus L.), based on shoot elongation induced in vitro, was demonstrated… 
Highly Cited
1990
Highly Cited
1990
Hepatic neoplasms in aflatoxin B1-treated, congenital duck hepatitis B virus-infected, and virus-free pekin ducks.
To assess the effects of the combination of persistent hepadnavirus infection and chemical carcinogen exposure, aflatoxin B1 (AFB… 
1987
1987
3-Pyrroline N-oxide bis(carbamate) tumor inhibitors as analogues of indicine N-oxide.
The 2,3-bis[[(N-methylcarbamoyl)oxy]methyl]-3-pyrroline 1-oxide 5 was synthesized and tested in the murine P388 lymphocytic… 
Review
1982
Review
1982
The Main Stages of the Late Quaternary Evolution of the Kalahari Region, Southern Africa
The palaeogeographical and palaeoclimatic development of the Kalahari region provides strong evidence that South African climatic… 
Highly Cited
1979
Highly Cited
1979
Dynamics of neoplastic development in carcinogen-exposed tracheal mucosa.
The qualitative and quantitative cellular changes occurring in tracheal epithelium in vivo during the process of carcinogenesis… 
1979
1979
Toxicity and pharmacokinetics of a pyrrolizidine alkaloid, indicine N-oxide, in humans.
Abstract Indicine N-oxide (NSC 132319), the first pyrrolizidine alkaloid to be studied as an antitumor agent in humans, was… 
Highly Cited
1972
Highly Cited
1972
Cerebral blood flow following induced subarachnoid hemorrhage in the monkey.
✓ The acute effects of experimental subarachnoid hemorrhage on cerebral blood flow were investigated in 14 adult rhesus monkeys… 
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