indicine-N-oxide

Known as: Butanoic Acid, 2,3-Dihydroxy-2-(1-methylethyl)- (2,3,5, 7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) Methyl Ester, N-Oxide,(1R-(1alpha,7(2R*,3S*),7a-beta))-(9CI), 2,3-dihydroxy-2-(1-methylethyl) butanoic acid (2,3,5,7a-tetrahydro-1-hydroxy- 1H-pyrrolizin-7-yl)methyl ester N-oxide, INDI 
A natural pyrrolizidine alkaloid with antineoplastic properties. Indicine-N-oxide alkylates and crosslinks DNA. (NCI04)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
As researchers increase their efforts to characterize variations in the functional connectome across studies and individuals… (More)
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Highly Cited
2013
Highly Cited
2013
Over a decade ago, the fMRI Data Center (fMRIDC) pioneered open-access data sharing in the task-based functional neuroimaging… (More)
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Highly Cited
2012
Highly Cited
2012
Neuropsychiatric imaging remains a pioneering frontier in modern medicine. Recent decades have witnessed marked advances in… (More)
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Highly Cited
2007
Highly Cited
2007
Oxaliplatin is effective in the treatment of metastatic colorectal cancer (MCRC) patients; however, severe neurotoxicity develops… (More)
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Highly Cited
2006
Highly Cited
2006
The best strategy for incorporating imatinib in front-line treatment of Ph+ acute lymphoblastic leukemia (ALL) has not been… (More)
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Highly Cited
1996
Highly Cited
1996
ENDOGENOUS neuromodulatory molecules are commonly coupled to specific metabolic enzymes to ensure rapid signal inactivation. Thus… (More)
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Highly Cited
1995
Highly Cited
1995
MUTATIONS in the KIT transmembrane protein-tyrosine kinase receptor1 affect erythropoiesis, resulting in fewer committed late… (More)
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Highly Cited
1991
Highly Cited
1991
We investigated the effects of 1 and 3 mM 2,3-butanedione monoxime (BDM, diacetyl monoxime) on excitation and contraction of… (More)
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1981
1981
Indicine-N-oxide, a pyrrolizidine derivative, was selected for development because of activity in the murine P388 leukemia model… (More)
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1976
1976
Extracts of Heliotropium indicum Linn. (Boraginaceae) showed significant activity in several experimental tumor systems. The… (More)
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