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improgan

 
National Institutes of Health

Papers overview

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2011
2011
The search for the mechanism of action of improgan (a nonopioid analgesic) led to the recent discovery of CC12, a compound that… Expand
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2010
2010
Many analgesic drugs, including μ-opioids, cannabinoids, and the novel nonopioid analgesic improgan, produce antinociception by… Expand
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2010
2010
Improgan, the prototype compound of a novel class of non-opioid analgesic drugs derived from histamine antagonists, attenuates… Expand
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2009
2009
Improgan, a cimetidine derivative which lacks activity at known histamine, opioid or cannabinoid receptors, acts by an unknown… Expand
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2007
2007
UNLABELLED Improgan is a congener of the H(2) antagonist cimetidine, which produces potent antinociception. Because a) the… Expand
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2007
2007
Improgan, a chemical congener of cimetidine, is a highly effective non-opioid analgesic when injected into the CNS. Despite… Expand
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2004
2004
Improgan is a compound developed from histamine antagonists which shows the pre-clinical profile of a highly effective, non… Expand
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2002
2002
Improgan, a nonopioid antinociceptive agent, activates descending, pain-relieving mechanisms in the brain stem, but the receptor… Expand
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2001
2001
Improgan is the prototype drug from a new class of non-opioid analgesics chemically related to histamine and histamine… Expand
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2000
2000
Improgan is an analog of the H(2) antagonist cimetidine that does not act on known histamine receptors, but induces highly… Expand
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