• Publications
  • Influence
Genomics meets histamine receptors: new subtypes, new receptors.
  • L. Hough
  • Biology, Medicine
  • Molecular pharmacology
  • 1 March 2001
Whether the job is waking the brain after a peaceful sleep, initiating gastric secretion when dinner is served or orchestrating the elements of inflammation after a mosquito bite, histamine has beenExpand
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  • PDF
Lateral asymmetry of neurotransmitters in human brain
Data recently published as indicating little or no evidence of neurotransmitter asymmetries in post-mortem human brain were analyzed by correlational and Chi-square procedures. Although handednessExpand
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Cellular localization and possible functions for brain histamine: Recent progress
  • L. Hough
  • Biology, Medicine
  • Progress in Neurobiology
  • 1988
  • 237
  • 5
Tissue distribution of ibogaine after intraperitoneal and subcutaneous administration.
The distribution of the putative anti-addictive substance ibogaine was measured in plasma, brain, kidney, liver and fat after ip and sc administration in rats. One hr after ip dosing (40 mg/kg), drugExpand
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Cimetidine penetrates brain and inhibits non-opiate footshock-induced analgesia
The inhibition of hindpaw (non-opiate) footshock-induced analgesia (HP-FSIA) by cimetidine, the histamine H2-receptor antagonist, was characterized in rats, and the drug's presence in brain wasExpand
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Rat Brain Mast Cells: Contribution to Brain Histamine Levels
Recent studies have shown that mast cells (MCs) are present in rat brain, that they have a predominantly thalamic localization, and that they contain histamine (HA). However, the degree to whichExpand
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  • 4
Activation of spinal histamine H3 receptors inhibits mechanical nociception.
Previous studies have suggested a possible pain-modulatory role for histamine H(3) receptors, but the localization of these receptors and nature of this modulation is not clear. In order to exploreExpand
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Sex Differences in Ibogaine Antagonism of Morphine-induced Locomotor Activity and in Ibogaine Brain Levels and Metabolism
The present study demonstrates that the putative antiaddictive agent ibogaine produces more robust behavioral effects in female than in male rats and that these behavioral differences correlate withExpand
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Mast cells in rat thalamus: Nuclear localization, sex difference and left-right asymmetry
Mast cells were positively identified in rat brain by a combination of staining and histochemical procedures. These cells stained positively with toluidine blue and Astrablau at low pH, indicatingExpand
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A role for histamine and H2-receptors in opioid antinociception.
To investigate the role of brain H2-receptors in opioid antinociceptive mechanisms, the effects of several antagonists of histamine H2-receptors were determined on morphine (MOR)-inducedExpand
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