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immunoglobulin heavy chain V-D-J recombination

Known as: immunoglobulin V(D)J recombination, immunoglobulin V-J recombination, immunoglobulin V-D-J recombination 
The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination… 
National Institutes of Health

Related topics

Related topics

1 relation
immunoglobulin light chain V-J recombination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Baseline VDJ clonotype detection using a targeted sequencing NGS assay: allowing for subsequent MRD assessment
Dear Editor, Fluorescent in situ hybridization (FISH), metaphase cytogenetics, and single nucleotide polymorphism (SNP… 
2016
2016
Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development
Zhao and collaborators use linear amplification–mediated high-throughput genome-wide translocation sequencing to examine TCRδ VDJ… 
2013
2013
Flexible ordering of antibody class switch and V(D)J joining during B-cell ontogeny
Omenn syndrome is a severe immunodeficiency disease commonly arising from hypomorphic RAG recombinase gene mutations. RAG… 
1995
1995
Mitogen activation of a nuclear alkaline phosphatase in normal activated lymphocytes.
B cell differentiation is punctuated by V(D)J joining in the heavy chain of the pro-B cell, VJ joining in the light chain of the… 
Highly Cited
1994
Highly Cited
1994
Antigen-specific human antibodies from mice comprising four distinct genetic modifications
HUMAN sequence monoclonal antibodies, which in theory combine high specificity with low immunogenicity, represent a class of… 
Highly Cited
1994
Highly Cited
1994
Analysis of regions of RAG-2 important for V(D)J recombination.
The recombinase activating genes RAG-1 and RAG-2 operate together to activate V(D)J recombination, and thus play an essential… 
Highly Cited
1994
Highly Cited
1994
Essential residues in V(D)J recombination signals.
Recombination signal sequences for V(D)J joining consist of a conserved heptamer (CACAGTG) and a nonamer (ACAAAAACC) separated by… 
Review
1994
Review
1994
P nucleotides, hairpin DNA and V(D)J joining: making the connection.
  • S. Lewis
  • Seminars in Immunology
  • 1994
  • Corpus ID: 33085713
The fine-structures of V(D)J joining products present a cache of information about the recombination process. Testable hypotheses… 
1991
1991
High expression of a 3'----5' exonuclease activity is specific to B lymphocytes
V(D)J joining, the immunoglobulin heavy-chain (IgH) class switch, and somatic hypermutation directed at variable regions are… 
1987
1987
A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences
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