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Conservation of the Notch signalling pathway in mammalian neurogenesis.
Conservation of the Notch pathway and its regulatory mechanisms from fly to mouse are demonstrated, and a role for the murine Notch signalling pathway in the regulation of neural stem cell differentiation is supported.
DNase II: genes, enzymes and function.
Regulation of the RAG-1 promoter by the NF-Y transcription factor.
We have cloned the RAG-1 promoter region and have determined that almost all detectable promoter activity resides within a 208-bp fragment. Sequence analysis of this promoter region has identified
Structure of acid deoxyribonuclease
It is demonstrated that recombinant Burkholderia thailandensis DNase II is highly active at low pH in the absence of divalent metal ions, similar to eukaryoticDNase II.
Titanocene-phosphine derivatives as precursors to cytotoxic heterometallic TiAu2 and TiM (M = Pd, Pt) compounds. Studies of their interactions with DNA.
A series of tri- and bimetallic titanium-gold, titanium-palladium, and titanium-platinum derivatives of the general formulas have been synthesized and characterized by different spectroscopic techniques and mass spectrometry, and all of these complexes show a stronger interaction with DNA than that displayed by Cp (2)TiCl(2) at neutral pH.
Recombinant human lactoferrin induces apoptosis, disruption of F-actin structure and cell cycle arrest with selective cytotoxicity on human triple negative breast cancer cells
Overall results suggest that rhLf is using the apoptosis pathway as its mechanism to inflict cell death on triple-negative breast cancer MDA-MB-231 cells, suggesting further evaluation ofrhLf as a potential anti-breast cancer drug option.
Searching in Mother Nature for Anti-Cancer Activity: Anti-Proliferative and Pro-Apoptotic Effect Elicited by Green Barley on Leukemia/Lymphoma Cells
Green barley extract has potential as an anti-leukemia/lymphoma agent alone or in combination with standard cancer therapies and thus warrants further evaluation in vivo to support these findings.