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iduronate-2-sulfatase activity

Known as: 2-sulfo-L-iduronate 2-sulfatase activity, L-iduronosulfatase activity, iduronate-2-sulfate sulfatase activity 
Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin. [EC:3.1.6.13… 
National Institutes of Health

Related topics

Related topics

2 relations
IDS gene

Broader (1)

chondroitinsulfatase activity

Papers overview

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1998
1998
New pathway of heparan sulphate degradation. Iduronate sulphatase and N-sulphoglucosamine 6-sulphatase act on the polymer chain prior to depolymerisation by a N-sulpho-glucosaminidase and…
1998
1998
Mucopolysaccharidosis type II (Hunter's syndrome) in Taiwan.
  • P. SuW. Hwu T. R. Wang
  • Journal of the Formosan Medical Association…
  • 1998
  • Corpus ID: 35454389
The mucopolysaccharidoses are a group of inherited disorders of lysosomal storage of glycosaminoglycans. Among them… 
1992
1992
Fragile X mental retardation and the iduronate sulphatase locus: testing Laird's model of fra(X) inheritance.
Fragile X [fra(X)] mental retardation syndrome is the most frequent familial cause of mental handicap. The clinical phenotype is… 
1987
1987
Hunter syndrome: presence of material cross-reacting with antibodies against iduronate sulfatase
SummaryPolyclonal antibodies were obtained from rabbits by injection of iduronate sulfatase purified 35,000-fold from human… 
1982
1982
Administration of iduronate sulfatase by plasma exchange to patients with the Hunter syndrome: a clinical study.
The Hunter syndrome (MPS II) is the only mucopolysaccharidosis in which there is appreciable activity of the deficient enzyme in… 
1980
1980
Interaction between heparan sulphate chains. II. Structural characterization of iduronate- and glucuronate-containing sequences in aggregating chains.
1979
1979
alpha-L-iduronidase, beta-D-glucuronidase, and 2-sulfo-L-iduronate 2-sulfatase: preparation and characterization of radioactive substrates from heparin.
Radioactive disaccharide substrates for alpha-L-iduronidase, beta-D-glucuronidase, and 2-sulfo-L-iduronate 2-sulfatase have been… 
1977
1977
Iduronate sulfatase in amniotic fluid: an aid in the prenatal diagnosis of the hunter syndrome.
Highly Cited
1976
Highly Cited
1976
Iduronate Sulfatase Activity in Serum, Lymphocytes, and Fibroblasts—Simplified Diagnosis of the Hunter Syndrome
Extract: A previously described assay for iduronate sulfatase has been adapted for use with serum, lymphocytes, and fibroblasts… 
1976
1976
Iduronate sulfatase determination for the diagnosis of the Hunter syndrome and the detection of the carrier state.
The research efforts of the last few years have clarified the biochemical basis of the mucopolysaccharidoses (17). Some practical… 
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