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Heparan sulfate proteoglycans: structure, protein interactions and cell signaling.
- J. Dreyfuss, C. Regatieri, Thais R Jarrouge, R. P. Cavalheiro, L. O. Sampaio, H. Nader
- Biology, ChemistryAnais da Academia Brasileira de Ciencias
- 1 September 2009
The structural characteristics of the heparan sulfate proteoglycans related to protein interactions leading to cell signaling and endocytic uptake pathways are focused on.
A novel expression profile of the Loxosceles intermedia spider venomous gland revealed by transcriptome analysis.
An important overview of the L. intermedia venom gland expression scenario is provided and it is confirmed that this venom constitutes an amazing source of novel compounds with potential agrochemical, industrial and pharmacological applications.
Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin
- Courtney J. Mycroft-West, Dunhao Su, M. Skidmore
- Biology, ChemistryThrombosis and haemostasis
- 1 December 2020
It is shown that heparin inhibits severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) invasion of Vero cells by up to 80% at doses achievable through prophylaxis and, particularly relevant, within the range deliverable by nebulisation.
Distribution of sulfated glycosaminoglycans in the animal kingdom: widespread occurrence of heparin-like compounds in invertebrates.
Structure and pharmacological activities of a sulfated xylofucoglucuronan from the alga Spatoglossum schröederi
Purification and substrate specificity of heparitinase I and heparitinase II from Flavobacterium heparinum. Analyses of the heparin and heparan sulfate degradation products by 13C NMR spectroscopy.
Brown spider dermonecrotic toxin directly induces nephrotoxicity.
Structure and antithrombin-binding properties of heparin isolated from the clams Anomalocardia brasiliana and Tivela mactroides.
Structural and Hemostatic Activities of a Sulfated Galactofucan from the Brown Alga Spatoglossum schroederi
The sulfated galactofucan was 2-fold more potent than heparin in stimulating the synthesis of an antithrombotic heparan sulfate by endothelial cells, and suggested that this last effect may be related to the “in vivo” antithROMbotic activity of this polysaccharide.
Crotamine Mediates Gene Delivery into Cells through the Binding to Heparan Sulfate Proteoglycans*
- F. D. Nascimento, M. Hayashi, I. Kerkis
- Biology, ChemistryJournal of Biological Chemistry
- 20 July 2007
It is shown that this toxin at non-toxic concentrations is also capable of binding electrostatically to plasmid DNA forming DNA-peptide complexes whose stabilities overcome the need for chemical conjugation for carrying nucleic acids into cells.