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ibutilide

Known as: ibutilide [Chemical/Ingredient], Ibutilidum, N-(4-{4-[ethyl(heptyl)amino]-1-hydroxybutyl}phenyl)methanesulfonamide 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (2)

Anti-Arrhythmia AgentsSulfonamides
Atrial FibrillationAtrial FlutterDrug Allergy

Narrower (3)

U-82208EU-82209Eibutilide fumarate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat.
Highly Cited
2006
Highly Cited
2006
Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval.
Highly Cited
2006
Highly Cited
2006
Drug Binding Interactions in the Inner Cavity of hERG Channels: Molecular Insights from Structure-Activity Relationships of Clofilium and Ibutilide Analogs
Block of human ether-a-go-go related gene (hERG) K+ channels by otherwise useful drugs is the most common cause of long QT… 
Highly Cited
2004
Highly Cited
2004
Structural Determinants of HERG Channel Block by Clofilium and Ibutilide
Block of human ether-a-go-go related gene (HERG) K+ channels by a variety of medications has been linked to acquired long QT… 
Highly Cited
2003
Highly Cited
2003
Detection of Proarrhythmia in the Female Rabbit Heart:
Introduction: Reliable detection of drug‐induced proarrhythmia, especially the potential for polymorphic ventricular tachycardia… 
Highly Cited
2001
Highly Cited
2001
Drug-induced QT prolongation in women during the menstrual cycle.
CONTEXT Women have a higher incidence of torsades de pointes than men, but it is not known if the risk of drug-induced torsades… 
Review
1999
Review
1999
Pharmacologic versus direct-current electrical cardioversion of atrial flutter and fibrillation.
Highly Cited
1998
Highly Cited
1998
Frequency analysis of human atrial fibrillation using the surface electrocardiogram and its response to ibutilide.
Highly Cited
1995
Highly Cited
1995
Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent…
BACKGROUND Ibutilide is an action potential-prolonging antiarrhythmic currently in clinical trials. The drug shares structural… 
Highly Cited
1992
Highly Cited
1992
Ibutilide, a new compound with potent class III antiarrhythmic activity, activates a slow inward Na+ current in guinea pig ventricular cells.
Ibutilide, a class III antiarrhythmic compound under clinical development, was tested for specific activity on inward currents in… 
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