hypothemycin
National Institutes of Health
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The RAS/RAF/MEK/ERK signaling pathway has been targeted with a number of small molecule inhibitors in oncology clinical…
Sixteen polyketides belonging to diverse structural classes, including monomeric/dimeric tetrahydroxanthones and resorcylic acid…
The antifungal activity of a natural resorcylic acid lactone, hypothemycin (HPM), against Peronophythora litchii in vitro and in…
Protein kinases are potentially attractive therapeutic targets for neglected parasitic diseases, including African…
The impact of crystalline forces on the solid-state circular dichroism (CD) spectrum of hypothemycin (), a biologically active…
Design of irreversible inhibitors is an emerging and relatively less explored strategy for the design of protein kinase…
The resorcylic acid lactone hypothemycin has been shown to inactivate protein kinases by binding to a cysteine conserved in 46…
The resorcylic acid lactones (RAL) are endowed with diverse biological activity ranging from transcription factor modulators…
This subset of the kinome accounts for less than 10% of all identified kinases but includes several targets implicated in…
Three new hypothemycin analogues were isolated from the fungal strains Hypomyces subiculosus DSM 11931 and DSM 11932. The…