The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells.

@article{Fukazawa2010TheRA,
  title={The resorcylic acid lactone hypothemycin selectively inhibits the mitogen-activated protein kinase kinase-extracellular signal-regulated kinase pathway in cells.},
  author={Hidesuke Fukazawa and Yoshimi Ikeda and Mari Fukuyama and Takeshi Suzuki and Hiroshi Hori and Toru Okuda and Yoshimasa Uehara},
  journal={Biological & pharmaceutical bulletin},
  year={2010},
  volume={33 2},
  pages={168-73}
}
The resorcylic acid lactone hypothemycin has been shown to inactivate protein kinases by binding to a cysteine conserved in 46 protein kinases, including mitogen-activated protein kinase kinase (MEK), extracellular signal-regulated kinase (ERK) and platelet-derived growth factor receptor (PDGFR). We assessed the selectivity of hypothemycin in cellular… CONTINUE READING