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hygrolidin

 
National Institutes of Health

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Macrolides

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2020
2020
Catenulisporidins A and B, 16-membered macrolides of the hygrolidin family produced by the chemically underexplored actinobacterium Catenulispora species.
Two new macrolide metabolites of the hygrolidin family, catenulisporidins A and B (1 and 2), together with a known compound… Expand
2015
2015
High-Throughput Screening Platform for Natural Product–Based Drug Discovery Against 3 Neglected Tropical Diseases
African trypanosomiasis, leishmaniasis, and Chagas disease are 3 neglected tropical diseases for which current therapeutic… Expand
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2011
2011
New species of actinomycetes do not always produce new compounds with high frequency
Actinomycetes have been extensively studied for their ability to produce pharmaceutically useful compounds, however, the rate of… Expand
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2010
2010
Hygrobafilomycin, a cytotoxic and antifungal macrolide bearing a unique monoalkylmaleic anhydride moiety, from Streptomyces varsoviensis
A new bafilomycin-type macrolide, named hygrobafilomycin (6), was isolated by a bioassay-guided selection and fractionation from… Expand
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2002
2002
Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases.
Hygrolidin family antibiotics showed selective cytotoxicity against both cyclin E- and cyclin A-overexpressing cells. Among them… Expand
1993
1993
PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. II. Isolation, physico-chemical properties and structure elucidation.
A new macrolide antibiotic, PC-766B, was isolated from the cells of Nocardia brasiliensis SC-4710 by acetone extraction, and… Expand
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1991
1991
Inhibition of pinocytosis by hygrolidin family antibiotics: possible correlation with their selective effects on oncogene-expressed cells.
A fermentation broth of Streptomyces sp. SIPI-A4-0044 inhibited in vitro growth of src or ras oncogene-expressed (onc+) cells… Expand
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