hydroxyfasudil
National Institutes of Health
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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with no effective treatment. Fasudil hydrochloride…
ROCK or Rho-associated kinase, a serine/threonine kinase, is an effector of Rho-dependent signaling and is involved in actin…
Objective—Rho-Kinase activity is increased in cardiovascular diseases and in patients with cardiovascular risk factors. However…
Abstract— Intracellular signaling pathway mediated by small GTPase Rho and its effector Rho-kinase plays an important role in…
Background—Hypoxia-induced pulmonary hypertension is a major cause of morbidity and mortality. Hypoxia induces pulmonary…
Rho-kinase plays an important role in calcium sensitization for vascular smooth muscle (VSMC) contraction and may be involved in…
The effects of Rho‐kinase inhibitor, fasudil, and of a more specific Rho‐kinase inhibitor, hydroxyfasudil, on pacing‐induced…