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holocarboxylase synthetases

Known as: biotin holocarboxylase synthetase, holoenzyme synthetase 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Carbon-Nitrogen Ligases
HLCS gene

Papers overview

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Highly Cited
2005
Highly Cited
2005
Crystal Structure of Lipoate-Protein Ligase A Bound with the Activated Intermediate
Lipoic acid is the covalently attached cofactor of several multi-component enzyme complexes that catalyze key metabolic reactions… 
2002
2002
Binding specificity and the ligand dissociation process in the E. coli biotin holoenzyme synthetase
The binding of the Escherichia coli biotin holoenzyme synthetase to the two ligands, biotin and bio‐5′‐AMP, is coupled to… 
1998
1998
Purification and properties of the chloroplastic form of biotin holocarboxylase synthetase from Arabidopsis thaliana overexpressed in Escherichia coli.
Holocarboxylase synthetases (HCSs) are key enzymes in biotin utilisation in both prokaryotes and eukaryotes. In a previous study… 
Highly Cited
1996
Highly Cited
1996
A versatile plasmid expression vector for the production of biotinylated proteins by site-specific, enzymatic modification in Escherichia coli.
1996
1996
Thermodynamic analysis of small ligand binding to the Escherichia coli repressor of biotin biosynthesis.
BirA is the transcriptional repressor of biotin biosynthesis and a biotin holoenzyme synthetase. It catalyzes synthesis of… 
Highly Cited
1994
Highly Cited
1994
Sequence requirements for the biotinylation of carboxyl-terminal fragments of human propionyl-CoA carboxylase alpha subunit expressed in Escherichia coli.
Biotin-dependent enzymes play an essential role in the metabolism of all organisms. Their biotinylation is catalyzed by… 
1984
1984
Formation of N epsilon-(biotinyl)lysine in biotin enzymes.
Highly Cited
1981
Highly Cited
1981
Genetic and biochemical characterization of the birA gene and its product: evidence for a direct role of biotin holoenzyme synthetase in repression of the biotin operon in Escherichia coli.
1980
1980
Biotin regulatory (bir) mutations of Escherichia coli
Most mutants selected for derepression of the biotin operon required elevated concentrations of biotin for growth. Mutant… 
1971
1971
Synthesis of pyruvate carboxylase from its apoenzyme and (+)-biotin in Bacillus stearothermophilus. Mechanism and control of the reaction.
1. Acetyl-CoA acts as a positive allosteric effector in the formation of active pyruvate carboxylase from its apoenzyme, ATP and… 
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