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histone methyltransferase activity

Known as: histone methylase activity 
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

histone methylation

Narrower (1)

histone-arginine N-methyltransferase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
G9a-mediated repression of CDH10 in hypoxia enhances breast tumour cell motility and associates with poor survival outcome
Rationale: Epigenetic mechanisms are fundamental processes that can modulate gene expression, allowing cellular adaptation to… 
2019
2019
Ash1 counteracts Polycomb repression independent of histone H3 lysine 36 methylation
Polycomb repression is critical for metazoan development. Equally important but less studied is the Trithorax system, which… 
2018
2018
Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage
The enzyme Poly(ADP-ribose) polymerase 1 (PARP1) plays a very important role in the DNA damage response, but its role in numerous… 
2018
2018
Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish
Abstract EZH2 is a subunit of polycomb repressive complex 2 (PRC2) that silences gene transcription via H3K27me3 and was shown to… 
2016
2016
DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity
EZH2 is a histone methyltransferase whose functions in stem cells and tumor cells are well established. Accumulating evidence… 
2014
2014
Gene regulation: Yin and Yang of Polycomb/Trithorax response elements
A PRE/TRE is shown to alter gene expression by transcribing two mutually exclusive ncRNAs from opposing DNA strands in different… 
2013
2013
Inhibition of PRC2 histone methyltransferase activity increases TRAIL‐mediated apoptosis sensitivity in human colon cancer cells
Colorectal cancer is ranked among the top leading causes of cancer death in industrialized populations. Polycomb group proteins… 
2013
2013
EZH2 overexpression in natural killer /T-cell lymphoma confers growth advantage independently of histone methyltransferase activity
The role of EZH2 in cancer is complex and may vary depending on the cellular context. We found that EZH2 is aberrantly… 
Highly Cited
2009
Highly Cited
2009
Requirement of Histone Methyltransferase SMYD3 for Estrogen Receptor-mediated Transcription*
SMYD3 is a SET domain-containing protein with histone methyltransferase activity on histone H3–K4. Recent studies showed that… 
1974
1974
Changes in histone methylase activity of rat brain and liver with ageing
No function has been found for the methylation of the ɛ-N-amino group of lysine in certain histones that have been demonstrated… 
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