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Comprehensive analysis of the chromatin landscape in Drosophila
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here weExpand
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Genome-wide analysis of Polycomb targets in Drosophila melanogaster
Polycomb group (PcG) complexes are multiprotein assemblages that bind to chromatin and establish chromatin states leading to epigenetic silencing. PcG proteins regulate homeotic genes in flies andExpand
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Polycomb silencing mechanisms and the management of genomic programmes
Polycomb group complexes, which are known to regulate homeotic genes, have now been found to control hundreds of other genes in mammals and insects. First believed to progressively assemble andExpand
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Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines. Expand
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Alternative Epigenetic Chromatin States of Polycomb Target Genes
Polycomb (PcG) regulation has been thought to produce stable long-term gene silencing. Genomic analyses in Drosophila and mammals, however, have shown that it targets many genes, which can switchExpand
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A new world of Polycombs: unexpected partnerships and emerging functions
Polycomb group (PcG) proteins are epigenetic repressors that are essential for the transcriptional control of cell differentiation and development. PcG-mediated repression is associated with specificExpand
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Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome
The cohesin complex is a chromosomal component required for sister chromatid cohesion that is conserved from yeast to man. The similarly conserved Nipped-B protein is needed for cohesin to bind toExpand
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An assessment of histone-modification antibody quality
We have tested the specificity and utility of more than 200 antibodies raised against 57 different histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human cells. AlthoughExpand
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Nature and function of insulator protein binding sites in the Drosophila genome.
Chromatin insulator elements and associated proteins have been proposed to partition eukaryotic genomes into sets of independently regulated domains. Here we test this hypothesis by quantitativeExpand
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Polycomb complexes and epigenetic states.
Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shownExpand
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