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- Publications
- Influence
Comprehensive analysis of the chromatin landscape in Drosophila
- P. Kharchenko, A. A. Alekseyenko, +27 authors P. Park
- Biology, Medicine
- Nature
- 1 December 2010
Chromatin is composed of DNA and a variety of modified histones and non-histone proteins, which have an impact on cell differentiation, gene regulation and other key cellular processes. Here we… Expand
Genome-wide analysis of Polycomb targets in Drosophila melanogaster
- Y. Schwartz, T. Kahn, +4 authors V. Pirrotta
- Biology, Medicine
- Nature Genetics
- 1 April 2006
Polycomb group (PcG) complexes are multiprotein assemblages that bind to chromatin and establish chromatin states leading to epigenetic silencing. PcG proteins regulate homeotic genes in flies and… Expand
Polycomb silencing mechanisms and the management of genomic programmes
- Y. Schwartz, V. Pirrotta
- Biology, Medicine
- Nature Reviews Genetics
- 2007
Polycomb group complexes, which are known to regulate homeotic genes, have now been found to control hundreds of other genes in mammals and insects. First believed to progressively assemble and… Expand
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
- S. Roy, J. Ernst, +93 authors Manolis Kellis
- Biology, Computer Science
- Science
- 1 December 2010
TLDR
Alternative Epigenetic Chromatin States of Polycomb Target Genes
- Y. Schwartz, T. Kahn, P. Stenberg, Katsuhito Ohno, R. Bourgon, V. Pirrotta
- Biology, Medicine
- PLoS genetics
- 1 January 2010
Polycomb (PcG) regulation has been thought to produce stable long-term gene silencing. Genomic analyses in Drosophila and mammals, however, have shown that it targets many genes, which can switch… Expand
A new world of Polycombs: unexpected partnerships and emerging functions
- Y. Schwartz, V. Pirrotta
- Biology, Medicine
- Nature Reviews Genetics
- 1 December 2013
Polycomb group (PcG) proteins are epigenetic repressors that are essential for the transcriptional control of cell differentiation and development. PcG-mediated repression is associated with specific… Expand
Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome
- Ziva Misulovin, Y. Schwartz, +8 authors D. Dorsett
- Biology, Medicine
- Chromosoma
- 1 February 2008
The cohesin complex is a chromosomal component required for sister chromatid cohesion that is conserved from yeast to man. The similarly conserved Nipped-B protein is needed for cohesin to bind to… Expand
An assessment of histone-modification antibody quality
- Thea A. Egelhofer, Aki Minoda, +30 authors J. Lieb
- Biology, Medicine
- Nature Structural &Molecular Biology
- 10 November 2010
We have tested the specificity and utility of more than 200 antibodies raised against 57 different histone modifications in Drosophila melanogaster, Caenorhabditis elegans and human cells. Although… Expand
Nature and function of insulator protein binding sites in the Drosophila genome.
- Y. Schwartz, D. Linder-Basso, +17 authors V. Pirrotta
- Biology, Medicine
- Genome research
- 1 November 2012
Chromatin insulator elements and associated proteins have been proposed to partition eukaryotic genomes into sets of independently regulated domains. Here we test this hypothesis by quantitative… Expand
Polycomb complexes and epigenetic states.
- Y. Schwartz, V. Pirrotta
- Biology, Medicine
- Current opinion in cell biology
- 1 June 2008
Important advances in the study of Polycomb Group (PcG) complexes in the past two years have focused on the role of this repressive system in programing the genome. Genome-wide analyses have shown… Expand