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Oral Cavity and Esophageal Carcinogenesis Modeled in Carcinogen-Treated Mice
Interestingly, similar features of carcinogenesis, including multiple, large exophytic papillary squamous tumors and invasive squamous cell carcinomas, increased bromodeoxyuridine staining, and increased K14 expression, were also observed in the esophagi of 4-NQO-treated mice. Expand
Specific expression of a retinoic acid-regulated, zinc-finger gene, Rex-1, in preimplantation embryos, trophoblast and spermatocytes.
The results suggest that Rex-1 is involved in trophoblast development and spermatogenesis, and is a useful marker for studies of early cell fate determination in the ICM. Expand
Rex-1, a Gene Encoding a Transcription Factor Expressed in the Early Embryo, Is Regulated via Oct-3/4 and Oct-6 Binding to an Octamer Site and a Novel Protein, Rox-1, Binding to an Adjacent Site
It is shown here that the Oct-3/4 transcription factor, but not Oct-1, can either activate or repress theRex-1 promoter, depending on the cellular environment, and that a novel element also contributes to Rex-1 expression. Expand
Cellular biology and biochem-istry of the retinoids
This chapter discusses the cellular biology and biochemistry of the retinoids, and the ability of retinoic acid to promote terminal differentiation of neoplastic cells to nonneoplastic cell types. Expand
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and
How aberrant functioning of components of the stem cell regulatory network may contribute to malignant transformation of adult stem cells and the establishment of a "cancer stem cell" phenotype and thereby underlie multiple types of human malignancies is described. Expand
Retinoids, retinoic acid receptors, and cancer.
Successful cancer therapy with retinoids is likely to require combination therapy with drugs that regulate the epigenome, such as DNA methyltransferase and histone deacetylase inhibitors, as well as classical chemotherapeutic agents. Expand
Identification of a retinoic acid responsive enhancer 3′ of the murine homeobox gene Hox-1.6
The results support the idea that RA is an endogenous vertebrate morphogen; identification of the RA-responsive enhancer downstream of Hox-1.6 demonstrates that RA directly controls the transcription of at least one member of a gene family that determines tissue identity in the vertebrate embryo. Expand
Retinoids and vertebrate development.
  • L. Gudas
  • Medicine, Biology
  • The Journal of biological chemistry
  • 3 June 1994
In conclusion, it is obvious that many of the abnormalities in pattern formation and organ formation that result from the exogenous addition of RA during embryogenesis are related at least in part toExpand
Retinoic Acid-responsive Enhancers Located 3′ of the Hox A and Hox B Homeobox Gene Clusters
The Hoxa-1 and Hoxb-1 genes possess 3′ enhancers with similar sequences through which their expression and responsiveness to endogenous retinoids are controlled. Expand
Overexpression of the cellular retinoic acid binding protein-I (CRABP- I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells
The results support the idea that CRABP-I sequesters RA within the cell and thereby prevents RA from acting to regulate differentiation specific gene expression, and suggest a mechanism whereby the level of CRA BP-I can regulate responsiveness to RA during development. Expand