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high throughput screening

Known as: High Throughput Assay 
Use of robots and other automated techniques to screen large numbers of samples.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy
The tumour microenvironment contributes to cancer metastasis and drug resistance. However, most high throughput screening (HTS… 
Review
2014
Review
2014
Inhibitors of pancreatic lipase: state of the art and clinical perspectives
Obesity is a disorder of lipid metabolism and continues to be a global problem, ranking fifth for deaths worldwide. It also leads… 
Highly Cited
2011
Highly Cited
2011
Predictive Model of Rat Reproductive Toxicity from ToxCast High Throughput Screening1
The U.S. Environmental Protection Agency's ToxCast research program uses high throughput screening (HTS) for profiling… 
Highly Cited
2011
Highly Cited
2011
Differential nuclear staining assay for high-throughput screening to identify cytotoxic compounds.
As large quantities of novel synthetic molecules continue to be generated there is a challenge to identify therapeutic agents… 
Highly Cited
2010
Highly Cited
2010
A Grid Algorithm for High Throughput Fitting of Dose-Response Curve Data
We describe a novel algorithm, Grid algorithm, and the corresponding computer program for high throughput fitting of dose… 
Review
2008
Review
2008
Recent developments in fragment-based drug discovery.
The field of fragment-based drug discovery (FBDD) has developed significantly over the past 10 years and is now recognized as a… 
Highly Cited
2005
Highly Cited
2005
Discovery and optimization of new chromium catalysts for ethylene oligomerization and polymerization aided by high-throughput screening.
High throughput screening (HTS) of a 205 member Schiff base salicylaldimine ligand library derived from salicylaldehydes bearing… 
Highly Cited
2003
Highly Cited
2003
N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist.
Highly Cited
2001
Highly Cited
2001
Validation of FLIPR Membrane Potential Dye for High Throughput Screening of Potassium Channel Modulators
A fluorescence-based assay using the FLIPR Membrane Potential Assay Kit (FMP) was evaluated for functional characterization and… 
Highly Cited
2000
Highly Cited
2000
Development of High Throughput Screening Assays Using Fluorescence Polarization: Nuclear Receptor-Ligand-Binding and Kinase/Phosphatase Assays
Fluorescence polarization (FP) has been used to develop high throughput screening (HTS) assays for nuclear receptor-ligand… 
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