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Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling
Heterodimerization of TLR2 with TLR1 or TLR6 evolutionarily developed to expand the ligand spectrum to enable the innate immune system to recognize the numerous, different structures of LP present in various pathogens.
Isolation, Structure Elucidation, and Synthesis of a Macrophage Stimulatory Lipopeptide from Mycoplasma fermentans Acting at Picomolar Concentration
- P. Mühlradt, M. Kiess, H. Meyer, R. Süssmuth, G. Jung
- Chemistry, BiologyThe Journal of experimental medicine
- 2 June 1997
Two mycoplasma-derived lipopeptides showed an identical dose dependency with a half-maximal response at 10−11 M concentration, suggesting MALP-2 may be one of the most potent natural macrophage stimulators besides endotoxin.
TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides*
A triacylation pattern is necessary but not sufficient to render a lipopeptide TLR1-dependent, and a diacylation patterns is necessarybut not sufficientTo render alipopeptides TLR6-dependent.
Lantibiotics—Ribosomally Synthesized Biologically Active Polypeptides containing Sulfide Bridges and α,β‐Didehydroamino Acids
- G. Jung
- Chemistry, Biology
- 1 September 1991
Conformational analyses of the lantibiotics, as well as of their prepeptides, enables one to obtain information about the mechanism and steps of the biosynthesis.
Toll‐like receptor 6‐independent signaling by diacylated lipopeptides
- U. Buwitt-Beckmann, H. Heine, A. Ulmer
- Biology, ChemistryEuropean journal of immunology
- 1 January 2005
The results indicate that both the lipid and the N‐terminal peptides of lipoproteins contribute to the specificity of recognition by TLR2 heteromers and are responsible for the ligand–receptor interaction on host cells.
Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings
It is proposed that the N-terminus (–30 to –1) plays a cooperative role during modification reactions and prevents toxicity of the mature epidermin to the producing strain before the antibiotic is cleaved off and secreted.
Identification and Analysis of the Balhimycin Biosynthetic Gene Cluster and Its Use for Manipulating Glycopeptide Biosynthesis in Amycolatopsis mediterranei DSM5908
- S. Pelzer, R. Süssmuth, W. Wohlleben
- Biology, EngineeringAntimicrobial Agents and Chemotherapy
- 1 July 1999
Structural analysis by high-performance liquid chromatography–mass spectrometry, fragmentation studies, and amino acid analysis demonstrated that these oxygenases are involved in the coupling of the aromatic side chains of the unusual heptapeptide.
Identification of High Potency Microbial and Self Ligands for a Human Autoreactive Class II–restricted T Cell Clone
For at least some autoreactive CD4+ T cells antigen recognition is highly degenerate and a completely random and unbiased approach such as combinatorial peptide libraries can decrypt the spectrum of stimulatory ligands for a T cell receptor (TCR).
Inhibition of virulence factor expression in Staphylococcus aureus by the Staphylococcus epidermidis agr pheromone and derivatives
High-performance liquid chromatography of siderophores from fungi
SummaryA reversed-phase HPLC separation of iron(III) chelates of 16 representative fungal siderophores including ferrichromes, coprogens and triacetylfusarinine C was established in order to…