heterocycle biosynthetic process

Known as: heterocycle synthesis, heterocycle biosynthesis, heterocycle formation 
The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two… (More)
National Institutes of Health

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2015
2015
Discovery of an oral respiratory syncytial virus (RSV) fusion inhibitor (GS-5806) and clinical proof of concept in a human RSV challenge study.
GS-5806 is a novel, orally bioavailable RSV fusion inhibitor discovered following a lead optimization campaign on a screening hit… (More)
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2012
2012
Heterocycle synthesis via direct C-H/N-H coupling.
A method for five- and six-membered heterocycle formation by palladium-catalyzed C-H/N-H coupling is presented. The method… (More)
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2012
2012
Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions.
Nucleic acid-encoded libraries are emerging as an attractive and highly miniaturized format for the rapid identification of… (More)
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2011
2011
Rhodium(III)-catalyzed heterocycle synthesis using an internal oxidant: improved reactivity and mechanistic studies.
Directing groups that can act as internal oxidants have recently been shown to be beneficial in metal-catalyzed heterocycle… (More)
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2010
2010
Intramolecular Fe(II)-catalyzed N-O or N-N bond formation from aryl azides.
Iron(II) bromide catalyzes the transformation of aryl and vinyl azides with ketone or methyl oxime substituents into 2,1… (More)
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2007
2007
Potent antimalarial activity of 2-aminopyridinium salts, amidines, and guanidines.
We describe the design, synthesis, and antimalarial activity of 60 bis-tertiary amine, bis-2(1 H)-imino-heterocycle, bis-amidine… (More)
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2004
2004
Very large electro-optic responses in H-bonded heteroaromatic films grown by physical vapour deposition.
A crucial goal for modern telecommunications systems is development of very high-speed components for broadband (>100 GHz), all… (More)
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2003
2003
DNA binding mode of the cis and trans geometries of new antitumor nonclassical platinum complexes containing piperidine, piperazine, or 4-picoline ligand in cell-free media. Relations to their…
The global modification of mammalian and plasmid DNAs by novel platinum compounds, cis- or trans-[PtCl(2)(NH(3))(Am)], where Am… (More)
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1998
1998
ATP/GTP hydrolysis is required for oxazole and thiazole biosynthesis in the peptide antibiotic microcin B17.
In the maturation of the Escherichia coli antibiotic Microcin B17, the product of the mcbA gene is modified posttranslationally… (More)
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1994
1994
Mechanism-based inhibition of thymidylate synthase by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate.
Thymidylate synthase (TS) from Lactobacillus casei is inhibited by 5-(trifluoromethyl)-2'-deoxyuridine 5'-monophosphate (CF3dUMP… (More)
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