hetacillin

Known as: Hétacilline, Hetacillinum, Phenazacillin

A semi-synthetic penicillin compound with bactericidal properties. Hetacillin is a prodrug that is converted to ampicillin via esterases. Ampicillin…

National Institutes of Health

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1982

1978

Hetacillin was oxidized with m-chloroperbenzoic acid to give the corresponding (R)- and (S)-sulfoxides. Ozonization of hetacillin…

1975

Sir: In the degradation of hetacillin (I) in aqueous solution, there are at least two possible reactions: the epimerization to 6…

1974

The conversion of hetacillin to ampicillin in aqueous solution was studied by hydroxylamine assay, IR analysis, and 14C-labeling…

Highly Cited

1973

Highly Cited

1973

Plasma concentrations of ampicillin and hetacillin were measured after intravenous administration to anephric patients (on and…

1972

Abstract Sodium ampicillin in solution loses almost 10% of its activity in 1 hr. at room temperature at a concentration of 250 mg…

1972

Ampicillin and hetacillin in aqueous solution showed distinctive chemical alterations within 1 day. Ampicillin formed polymers…

1970

Hetacillin breaks down in aqueous solution to give ampicillin and acetone, both of which products have been identified chemically…

1967

In addition to providing a broadened antimicrobial spectrum, the reactive basic group (NH,) in the ampicillin molecule confers…

1966