W. Jusko

Publications672
h-index71
Citations22,866
Highly Influential Citations705
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Comparison of four basic models of indirect pharmacodynamic responses
TLDR
Four basic models for characterizing indirect pharmacodynamic responses after drug administration have been developed and compared and it was found that the responses produced showed a slow onset and a slow return to baseline.
General Pharmacokinetic Model for Drugs Exhibiting Target-Mediated Drug Disposition
  • D. Mager, W. Jusko
  • Biology
    Journal of Pharmacokinetics and Pharmacodynamics
  • 1 December 2001
TLDR
The proposed model well captured the time-course of drug concentrations for the aldose reductase inhibitor imirestat, the endothelin receptor antagonist bosentan, and recombinant human interferon-β 1a.
Pharmacokinetics of tacrolimus in liver transplant patients
Applied pharmacokinetics : principles of therapeutic drug monitoring
The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and…
Pharmacokinetic and Pharmacodynamic Modeling of Recombinant Human Erythropoietin After Single and Multiple Doses in Healthy Volunteers
TLDR
A pharmacokinetic model to account for serum recombinant human erythropoietin (rHuEpo) concentrations in healthy volunteers following intravenous (IV) and subcutaneous (SC) dosing is described and the pharmacodynamics (PD) of SC rHuEPO effects on reticulocytes, red blood cells (RBC), and hemoglobin (Hb) in blood is characterized.
Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis.
The effects of drug stability, radioactive tracer purity, buffer composition, protein concentration, and fluid shifts on the nonlinear plasma protein binding of prednisolone were examined by…
Diversity of mechanism-based pharmacodynamic models.
TLDR
The purpose of this article is to describe the classic as well as contemporary approaches to pharmacodynamic modeling, with an emphasis on pertinent equations and salient model features.
Physiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous Doses
TLDR
A physiologically based pharmacokinetic model was developed to predict the concentration of FTY720 in various organs of the body and good agreement was found between the actual and predicted blood concentration-time profiles, including brain concentrations in dogs and humans.
Modeling of Corticosteroid Pharmacogenomics in Rat Liver Using Gene Microarrays
TLDR
The results reveal the marked diversity of genes regulated by CS via a limited array of mechanisms and new hypotheses regarding understanding of diverse mechanisms of CS receptor-gene mediated action are revealed.
Plasma and tissue protein binding of drugs in pharmacokinetics.
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