• Publications
  • Influence
General Pharmacokinetic Model for Drugs Exhibiting Target-Mediated Drug Disposition
  • D. Mager, W. Jusko
  • Chemistry, Medicine
  • Journal of Pharmacokinetics and Pharmacodynamics
  • 1 December 2001
Drugs that bind with high affinity and to a significant extent (relative to dose) to a pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear pharmacokinetic (PK)Expand
  • 420
  • 38
Pharmacokinetics of tacrolimus in liver transplant patients
To characterize the pharmacokinetics of the immunosuppressive agent tacrolimus (FK 506) in liver transplant patients.
  • 203
  • 16
Pharmacokinetic and Pharmacodynamic Modeling of Recombinant Human Erythropoietin After Single and Multiple Doses in Healthy Volunteers
This study describes a pharmacokinetic (PK) model to account for serum recombinant human erythropoietin (rHuEpo) concentrations in healthy volunteers following intravenous (IV) and subcutaneous (SC)Expand
  • 125
  • 15
Applied pharmacokinetics : principles of therapeutic drug monitoring
The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers andExpand
  • 662
  • 14
Fluid shifts and other factors affecting plasma protein binding of prednisolone by equilibrium dialysis.
The effects of drug stability, radioactive tracer purity, buffer composition, protein concentration, and fluid shifts on the nonlinear plasma protein binding of prednisolone were examined byExpand
  • 135
  • 13
Diversity of mechanism-based pharmacodynamic models.
TLDR
Pharmacodynamics is the study of the time course of pharmacological effects of drugs. Expand
  • 299
  • 12
  • PDF
Physiologically Based Pharmacokinetic Modeling of FTY720 (2-Amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) in Rats After Oral and Intravenous Doses
FTY720 (2-amino-2[2-(-4-octylphenyl)ethyl]propane-1,3-diol hydrochloride) is a new sphingosine-1-phosphate receptor agonist being developed for multiple sclerosis and prevention of solid organExpand
  • 121
  • 11
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Modeling of Corticosteroid Pharmacogenomics in Rat Liver Using Gene Microarrays
Corticosteroid (CS) pharmacogenomics was studied using gene microarrays in rat liver. Methylprednisolone (MPL) was administered intravenously at 50 mg/kg. Rats were sacrificed and liver excised at 17Expand
  • 99
  • 11
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Receptor-Mediated Pharmacokinetics and Pharmacodynamics of Interferon-β1a in Monkeys
A pharmacokinetic/pharmacodynamic (PK/PD) model was developed to simultaneously characterize interferon after i.v. and s.c. dosing at various dose levels. A sequential study in monkeys (n = 18) wasExpand
  • 76
  • 8
  • PDF
Pharmacodynamic Models for Agents that Alter Production of Natural Cells with Various Distributions of Lifespans
Indirect pharmacodynamic response (IDR) models were developed for agents which alter the generation of cell populations with arbitrary lifespan distributions. These models extend lifespan based IDRExpand
  • 40
  • 8