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heparin biosynthetic process

Known as: heparin formation, heparin biosynthesis, heparin synthesis 
The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000… Expand
National Institutes of Health

Papers overview

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2017
2017
Heparosan-coated liposomes for drug delivery
Liposomal encapsulation is a useful drug delivery strategy for small molecules, especially chemotherapeutic agents such as… Expand
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2011
2011
Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.
Deficiency of the heparan sulfate biosynthesis enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) in mice causes severely… Expand
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2011
2011
Controlled Photochemical Depolymerization of K5 Heparosan, a Bioengineered Heparin Precursor.
Heparosan is a polysaccharide, which serves as the critical precursor in heparin biosynthesis and chemoenzymatic synthesis of… Expand
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Highly Cited
2010
Highly Cited
2010
E. coli K5 fermentation and the preparation of heparosan, a bioengineered heparin precursor.
Heparosan is an acidic polysaccharide natural product, which serves as the critical precursor in heparin biosynthesis and in the… Expand
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2006
2006
Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells
Biosynthesis of heparin, a mast cell–derived glycosaminoglycan with widespread importance in medicine, has not been fully… Expand
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Highly Cited
2001
Highly Cited
2001
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.
The tumor suppressors EXT1 and EXT2 are associated with hereditary multiple exostoses and encode bifunctional… Expand
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1997
1997
Mouse mastocytoma cells synthesize undersulfated heparin and chondroitin sulfate in the presence of brefeldin A.
In order to study the subcellular localization and organization of the enzymes involved in the glycosylation of the hybrid… Expand
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Highly Cited
1991
Highly Cited
1991
Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.
We investigated the effects of a newly recognized multifunctional growth factor, the c-kit ligand stem cell factor (SCF), on… Expand
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1986
1986
Histamine and chondroitin sulfate E proteoglycan released by cultured human colonic mucosa: indication for possible presence of E mast cells.
An association between the release of histamine and chondroitin sulfate E proteoglycan (PG) was demonstrated in human colonic… Expand
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1981
1981
Effect of cycloheximide, beta-D-xylosides and beta-D-galactosides on heparin biosynthesis in mouse mastocytoma.
Heparin biosynthesis has been investigated with mouse mastocytoma in vitro. Minced tumour tissue catalysed the incorporation of… Expand
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