FAQ

heparin biosynthetic process

Known as: heparin formation, heparin biosynthesis, heparin synthesis 
The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000… (More)

Topic mentions per year

Topic mentions per year

1950-2017
01219502016

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Metabolic engineering of Chinese hamster ovary cells: towards a bioengineered heparin.
Heparin is the most widely used pharmaceutical to control blood coagulation in modern medicine. A health crisis that took place… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2011
2011
Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.
Deficiency of the heparan sulfate biosynthesis enzyme N-deacetylase/N-sulfotransferase 1 (NDST1) in mice causes severely… (More)
Is this relevant?
2006
2006
Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells.
Biosynthesis of heparin, a mast cell-derived glycosaminoglycan with widespread importance in medicine, has not been fully… (More)
Is this relevant?
2002
2002
Inhibition of heparin synthesis by methotrexate in rats in vivo.
The content and synthesis of heparin and mast cell-dependent skin oedema (as an indirect evaluation of histamine and serotonin… (More)
Is this relevant?
2001
2001
Altered processing of fibronectin in mice lacking heparin. a role for heparin-dependent mast cell chymase in fibronectin degradation.
We have previously generated a mouse strain with a defect in its heparin biosynthesis by targeting the gene for N-deacetylase/N… (More)
Is this relevant?
2001
2001
Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.
The tumor suppressors EXT1 and EXT2 are associated with hereditary multiple exostoses and encode bifunctional… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
1994
1994
cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin.
A 110-kDa protein involved in heparin biosynthesis in mouse mastocytoma cells was previously shown to express both glucosaminyl N… (More)
Is this relevant?
1992
1992
Search for the heparin antithrombin III-binding site precursor.
The last step of heparin biosynthesis is thought to involve the action of 3-O-sulfotransferase resulting in the formation of an… (More)
Is this relevant?
1981
1981
Effect of cycloheximide, beta-D-xylosides and beta-D-galactosides on heparin biosynthesis in mouse mastocytoma.
Heparin biosynthesis has been investigated with mouse mastocytoma in vitro. Minced tumour tissue catalysed the incorporation of… (More)
Is this relevant?
1950
1950
[Mast cells and heparin formation in hemorrhagic diathesis].
 
Is this relevant?