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Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.
In the rat, the effects of endothelin on the blood pressure vary from pressor (in pithed rats) to purely depressor in anesthetized rats where the resting blood pressure is high, and has the characteristics of a local pressor hormone, rather than a circulating one.
Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.
It is concluded that chronic nitric oxide blockade may constitute a new model of severe arterial hypertension.
Endothelin‐1 Participation in Overt and Inflammatory Pain
Endothelin-1 induced hyperalgesia in rats, abdominal constrictions in mice, incapacitation in dogs, and, when injected intradermally into humans, caused wheal and flare responses, which were accompanied by itching, indicating that ET-1 may play a role in modulating pain.
Acute inhibition of nitric oxide synthesis induces anxiolysis in the plus maze test.
Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.
Evidence is provided for the release of a nitric oxide-like factor from human neutrophils and mononuclear cells that, as in stimulated murine macrophages and endothelial cells, the precursor of this factor is L-arginine.
Sodium excess aggravates hypertension and renal parenchymal injury in rats with chronic NO inhibition.
Sodium overload aggravates the renal and systemic consequences of chronic NO inhibition by mechanisms that may include paradoxical activation of renin secretion, and interstitial expansion and glomerular ischemia constitute the chief modalities of renal injury in this model.
Receptor-mediated release of endothelium-derived relaxing factor and prostacyclin from bovine aortic endothelial cells is coupled.
Bovine aortic endothelial cells released EDRF and prostacyclin when stimulated with bradykinin and its analogues, or with ADP, ATP, arachidonic acid, and phospholipase C (phosphatidylcholine cholinephosphohydrolase, EC
Effects of acute nitric oxide inhibition on rat glomerular microcirculation.
It is suggested that EDRF exerts a basal relaxing effect on the glomerular microcirculation, as shown in rats the renal effect of acute administration of L-NMMA, a specific inhibitor of NO synthesis.
Endothelial progenitor cell mobilization and platelet microparticle release are influenced by clopidogrel plasma levels in stable coronary artery disease.
The balance between platelet MP release and EPC mobilization seems influenced by clopidogrel plasma levels, suggesting a protective mechanism on coronary artery disease.