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guanylate cyclase activator activity

Known as: guanylin 
Binds to and increases the activity of guanylate cyclase. [GOC:mah]
National Institutes of Health

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guanylate cyclase activity

Papers overview

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Highly Cited
2007
Highly Cited
2007
Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity.
BACKGROUND AND AIMS The most commonly lost gene products in colorectal carcinogenesis include guanylin and uroguanylin… 
Review
2004
Review
2004
Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics.
Highly Cited
2000
Highly Cited
2000
Uroguanylin treatment suppresses polyp formation in the Apc(Min/+) mouse and induces apoptosis in human colon adenocarcinoma cells via cyclic GMP.
The enteric peptides, guanylin and uroguanylin, are local regulators of intestinal secretion by activation of receptor-guanylate… 
Review
1996
Review
1996
Salt and water homeostasis: uroguanylin is a circulating peptide hormone with natriuretic activity.
Highly Cited
1994
Highly Cited
1994
Activation of intestinal CFTR Cl‐ channel by heat‐stable enterotoxin and guanylin via cAMP‐dependent protein kinase.
Heat‐stable enterotoxins (STa) produced by pathogenic bacteria induce profound salt and water secretion in the gut, leading to… 
Highly Cited
1994
Highly Cited
1994
Characterization of human uroguanylin: a member of the guanylin peptide family.
Guanylin, a peptide homologue of the bacterial heat-stable enterotoxins (ST), is an endogenous activator of guanylate cyclase C… 
Highly Cited
1994
Highly Cited
1994
Enterochromaffin cells of the digestive system: cellular source of guanylin, a guanylate cyclase-activating peptide.
Guanylin, a bioactive peptide, has recently been isolated from the intestine; this peptide activates intestinal guanylate cyclase… 
Highly Cited
1992
Highly Cited
1992
Rat guanylin cDNA: characterization of the precursor of an endogenous activator of intestinal guanylate cyclase.
Highly Cited
1992
Highly Cited
1992
Cloning and expression of guanylin. Its existence in various mammalian tissues.
Highly Cited
1992
Highly Cited
1992
Human guanylin: cDNA isolation, structure, and activity
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