• Publications
  • Influence
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway.
TLDR
A subset of olfactory neurons that express the cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D (GC-D) are found, suggesting that cG MP in these neurons also can have an important regulatory function in Olfactory signaling. Expand
Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors.
TLDR
The guanylyl cyclases represent an unexpectedly large and new family of sensory neuron receptors that may complement the 7-transmembrane family of odorant/pheromone receptors. Expand
A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.
TLDR
Observations suggest that GC-D may function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors. Expand
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
TLDR
The isolation, sequence and expression of a complementary DNA clone encoding the membrane form of guanylate cyclase from rat brain are reported, which represents a new class of mammalian cell-surface receptors which contain an extracellular ligand-binding domain and an intracellular guanyl cyclase catalytic domain. Expand
A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets
TLDR
An astonishing number of genes expressed specifically by male germ cells late in development provides a plethora of potential targets for germ cell-directed contraception and a staggering number of candidate proteins that could be critical for fertilization. Expand
Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs.
TLDR
The guanylyl cyclase B receptor is critical for the development of both bone and female reproductive organs and was due to the failure of the female reproductive tract to develop. Expand
Disruption of a Retinal Guanylyl Cyclase Gene Leads to Cone-Specific Dystrophy and Paradoxical Rod Behavior
TLDR
The GC-E-deficient mouse defines a model for cone dystrophy, but it also demonstrates that morphologically normal rods display paradoxical behavior in their responses to light. Expand
Hyperactivated sperm motility driven by CatSper2 is required for fertilization
TLDR
It is shown that disruption of the gene for a recently described sperm-specific voltage-gated cation channel, CatSper2, fails to significantly alter sperm production, protein tyrosine phosphorylation that is associated with capacitation, induction of the acrosome reaction, forward velocity, or percentage of motility, yet CatSar2–/– males are completely infertile. Expand
A new sperm-specific Na+/H+ Exchanger required for sperm motility and fertility
TLDR
Surprisingly, cyclic AMP analogues almost completely rescued the motility and infertility phenotypes of NHE-null males, and provides an attractive contraceptive target, given its cell-specific expression and absolute requirement for fertility. Expand
Guanylyl cyclase is a heat-stable enterotoxin receptor
TLDR
Results show that a heat-stable enterotoxin receptor responsible for acute diarrhea is a plasma membrane form of guanylyl cyclase. Expand
...
1
2
3
4
5
...