Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors.
- S. Yu, L. Avery, E. Baude, D. Garbers
- BiologyProceedings of the National Academy of Sciences…
- 1 April 1997
The guanylyl cyclases represent an unexpectedly large and new family of sensory neuron receptors that may complement the 7-transmembrane family of odorant/pheromone receptors.
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway.
- D. Juilfs, H. Fülle, A. Zhao, M. Houslay, D. Garbers, J. Beavo
- BiologyProceedings of the National Academy of Sciences…
- 1 April 1997
A subset of olfactory neurons that express the cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D (GC-D) are found, suggesting that cG MP in these neurons also can have an important regulatory function in Olfactory signaling.
A membrane form of guanylate cyclase is an atrial natriuretic peptide receptor
- Michael Chinkers, D. Garbers, S. Schulz
- BiologyNature
- 2 March 1989
The isolation, sequence and expression of a complementary DNA clone encoding the membrane form of guanylate cyclase from rat brain are reported, which represents a new class of mammalian cell-surface receptors which contain an extracellular ligand-binding domain and an intracellular guanyl cyclase catalytic domain.
A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets
- N. Schultz, F. K. Hamra, D. Garbers
- BiologyProceedings of the National Academy of Sciences…
- 2 October 2003
An astonishing number of genes expressed specifically by male germ cells late in development provides a plethora of potential targets for germ cell-directed contraception and a staggering number of candidate proteins that could be critical for fertilization.
A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons.
- H. Fülle, R. Vassar, D. Foster, R. Yang, R. Axel, D. Garbers
- BiologyProceedings of the National Academy of Sciences…
- 11 April 1995
Observations suggest that GC-D may function directly in odor recognition or in modulating the sensitivity of a subpopulation of sensory neurons to specific odors.
Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs.
- N. Tamura, L. Doolittle, R. Hammer, J. Shelton, J. Richardson, D. Garbers
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 7 December 2004
The guanylyl cyclase B receptor is critical for the development of both bone and female reproductive organs and was due to the failure of the female reproductive tract to develop.
Hyperactivated sperm motility driven by CatSper2 is required for fertilization
- T. Quill, Sarah A. Sugden, Kristen L. Rossi, L. Doolittle, R. Hammer, D. Garbers
- BiologyProceedings of the National Academy of Sciences…
- 1 December 2003
It is shown that disruption of the gene for a recently described sperm-specific voltage-gated cation channel, CatSper2, fails to significantly alter sperm production, protein tyrosine phosphorylation that is associated with capacitation, induction of the acrosome reaction, forward velocity, or percentage of motility, yet CatSar2–/– males are completely infertile.
Disruption of a Retinal Guanylyl Cyclase Gene Leads to Cone-Specific Dystrophy and Paradoxical Rod Behavior
- R. Yang, S. Robinson, W. Xiong, K. Yau, D. Birch, D. Garbers
- BiologyJournal of Neuroscience
- 15 July 1999
The GC-E-deficient mouse defines a model for cone dystrophy, but it also demonstrates that morphologically normal rods display paradoxical behavior in their responses to light.
The family of guanylyl cyclase receptors and their ligands.
- J. Drewett, D. Garbers
- Biology, ChemistryEndocrine reviews
- 1 April 1994
In the mid-1970s, three studies provided the first evidence that guanylyl cyclase activities were regulated in much the same manner as its already exciting sibling, adenylylcyclase.
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