FAQ

guanine phosphoribosyltransferase activity

Known as: guanosine phosphoribosyltransferase activity, GMP pyrophosphorylase activity, GPRT 
Catalysis of the reaction: GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate. [EC:2.4.2.8, GOC:curators]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1968-2017
02419682017

Papers overview

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2012
2012
Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease.
BACKGROUND Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme… (More)
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2010
2010
Antiproliferative effects induced by guanine-based purines require hypoxanthine-guanine phosphoribosyltransferase activity.
Guanine (GUA), guanosine and GMP exert a marked growth inhibition on the U87 glioma cell line that is not seen with other tested… (More)
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2005
2005
Association between cigarette smoking and hypoxanthine guanine phosphoribosyltransferase activity.
The aim of this study was to investigate the association between smoking behavior and hypoxanthine guanine… (More)
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2001
2001
Virtual screening of combinatorial libraries across a gene family: in search of inhibitors of Giardia lamblia guanine phosphoribosyltransferase.
Parasitic protozoa lack the ability to synthesize purine nucleotides de novo, relying instead on purine salvage enzymes for their… (More)
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1994
1994
Targeted and non-targeted actions of anti-cancer drugs.
(1) The currently used clinical anti-metabolites are targeted against-key enzymes of de novo purine and pyrimidine biosynthesis… (More)
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1992
1992
Regulation of GTP biosynthesis.
In the regulation of GTP biosynthesis, complex interactions are observed. A major factor is the behavior of the activity of IMPDH… (More)
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1981
1981
Hypoxanthine-guanine phosphoribosyltransferase activity in normal and leukaemic lymphocytes.
The levels of hypoxanthine-guanine phosphoribosyltransferase (HGPRT) were determined in lymphocytes from normal people and… (More)
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1979
1979
Hypoxanthine-guanine phosphoribosyltransferase activity of blood and muscle in Duchenne dystrophy.
Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) activity was measured in red cells and in skeletal muscles of normal and… (More)
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1975
1975
Appearance of hypoxanthine guanine phosphoribosyltransferase activity as a consequence of mycoplasma contamination
MYCOPLASMAS are common contaminants of cells in culture and are often responsible for profound alterations in the metabolism of… (More)
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1969
1969
Purine metabolism in heterozygous carriers of hypoxanthine-guanine phosphoribosyltransferase deficiency.
The urate pool and daily turnover of urate, together with the rate of incorporation of glycine into urate, were measured in three… (More)
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