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grazoprevir

Known as: (1aR,5S,8S,10R,22aR)-5-tert-butyl-N-{(1R,2S)-1-[(cyclopropanesulfonyl)carbamoyl]-2-ethenylcyclopropyl}-14-methoxy-3,6-dioxo-1,1a,3,4,5,6,9,10,18,19,20,21,22,22a-tetradecahydro-8H-7,10-methanocyclopropa[18,19][1,10,3,6]dioxadiazacyclononadecino[11,12-b]quinoxaline-8-carboxamide 
National Institutes of Health

Related topics

Related topics

6 relations
Breast Cancer Resistance Protein Inhibitors [MoA]HCV NS3/4A Protease Inhibitors [MoA]Hepatitis Celbasvir / grazoprevir

Broader (1)

MK-5172

Narrower (1)

Zepatier

Papers overview

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2018
2018
Hepatitis debrief from AASLD 2017
งานประชมโรคตบ American Association for the Study of Liver Diseases (AASLD) เมอป 2017… 
2017
2017
Analytical Method Development and Validation of Elbasvir and Grazoprevir in Bulk and Tablet Formulations by Rp-HPLC
The aim of the study is to develop and validate a simple, accurate, precise and rapid isocratic reverse-phase high-performance… 
2016
2016
Picogram Level Quantification of Grazoprevir and Elbasvir with Deuterated Internal Standards in Human Plasma Samples by LC–ESI-MS/MS
A fixed oral dose combination of grazoprevir and elbasvir is used for the treatment of patients with genotypes 1&4 HCV infections… 
Review
2016
Review
2016
Safety and efficacy of elbasvir and grazoprevir for treatment of hepatitis C
ABSTRACT Introduction: The combination of elbasvir and grazoprevir in a single co-formulated tablet is highly effective for… 
2016
2016
Neue Therapieoption in der Pipeline
  • W. Zimmermann
  • MMW - Fortschritte der Medizin
  • 2016
  • Corpus ID: 46104796
2016
2016
Corrigendum: Safety and Efficacy of Ombitasvir/Paritaprevir/Ritonavir Plus Dasabuvir With or Without Ribavirin in HCV-Infected Patients Taking Concomitant Acid-Reducing Agents
Patients taking ARAs and PPIs were also excluded from phase 2 and 3 studies of the HCV regimen containing the NS3/4A protease… 
Review
2016
Review
2016
[Novel treatments for hepatitis C virus infection in chronic kidney disease].
Recent evidence has been accumulated showing a negative impact of chronic hepatitis C virus infection on survival in patients… 
2015
2015
Effi cacy and safety of grazoprevir ( MK-5172 ) and elbasvir ( MK-8742 ) in patients with hepatitis C virus and HIV co-infection ( C-EDGE CO-INFECTION ) : a non-randomised , open-label trial
Bonn University Hospital, Bonn, Germany (Prof J K Rockstroh MD); Chelsea and Westminster Hospital, London, UK (M Nelson MD… 
2015
2015
The Next Single-Pill HCV Regimen?
Work continues in the effort to develop a core set of hepatitis C virus (HCV) infection treatment regimens that require no more… 
2015
2015
Running title : HCV genotype 2-6 protease inhibitor resistance 7 8
44 Various protease inhibitors (PIs) are currently becoming available for treatment of hepatitis C virus 45 (HCV). For genotype 1…