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Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection.
TLDR
Once-daily ledipasvir-sofosbuvir with or without ribavirin for 12 or 24 weeks was highly effective in previously untreated patients with HCV genotype 1 infection. Expand
Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study
TLDR
In patients with chronic HBV infection, up to 5 years of treatment with tenofovir DF was safe and effective, and long-term suppression of HBV can lead to regression of fibrosis and cirrhosis. Expand
Genomewide Association Study of Severe Covid-19 with Respiratory Failure
TLDR
A 3p21.31 gene cluster is identified as a genetic susceptibility locus in patients with Covid-19 with respiratory failure and a potential involvement of the ABO blood-group system is confirmed. Expand
Tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B.
TLDR
Among patients with chronic HBV infection, tenofovir DF at a daily dose of 300 mg had superior antiviral efficacy with a similar safety profile as compared with adefovir dipivoxil at adaily dose of 10 mg through week 48. Expand
HEV identified in serum from humans with acute hepatitis and in sewage of animal origin in Spain.
TLDR
It is suggested that the HEV could be more widespread than previously thought, and new evidence of the close relationship between HEV strains detected in pigs and those from acute hepatitis patients is presented. Expand
Hepatitis E Virus Epidemiology in Industrialized Countries
TLDR
The results suggest that HEV may be more prevalent than previously considered in industrialized countries and that variants of the virus circulate simultaneously in one region. Expand
Efficacy of 24 weeks treatment with peginterferon alfa-2b plus ribavirin in patients with chronic hepatitis C infected with genotype 1 and low pretreatment viremia.
TLDR
Investigating this schedule in the era of pegylated interferon-alpha plus ribavirin for chronically infected patients with a low baseline HCV-RNA concentration found it may be treated for 24 weeks without compromising sustained virologic response rates. Expand
A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel
TLDR
A comprehensive review of the literature was used to gather country‐specific data on risk factors, prevalence, number of diagnosed individuals and genotype distribution of the hepatitis C virus (HCV) infection in selected European countries, Canada and Israel. Expand
The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer.
TLDR
The DNA methylomes presented provide evidence of the dynamic nature of the epigenome in contrast to the genome, and it is observed that the DNA methylome of these viruses evolves from an unmethylated to a highly methylated genome in association with the progression of the disease. Expand
Simeprevir with pegylated interferon alfa 2a or 2b plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-2): a randomised, double-blind,
TLDR
The primary efficacy endpoint was sustained virological response at 12 weeks after the planned end of treatment (SVR12) and the incidences of adverse events were similar in the simeprevir and placebo groups at 12 Weeks and for the entire treatment, irrespective of the peginterferon alfa used. Expand
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