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glycinexylidide

Known as: 2-amino-2',6'-acetoxylidide, glycylxylidide 
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
The effect of chronic renal failure (CRF) on the pharmacokinetics of lidocaine, a drug cleared almost exclusively by hepatic… Expand
Highly Cited
2004
Highly Cited
2004
OBJECTIVE To determine the influence of a low-dose constant rate infusion (LCRI; 50 microg kg(-1) minute(-1)) and high-dose CRI… Expand
Highly Cited
2000
Highly Cited
2000
A sensitive, selective and accurate high-performance liquid chromatographic-tandem mass spectrometric assay was developed and… Expand
1988
1988
The modulated receptor hypothesis states that sodium channels have a specific receptor for antiarrhythmic drugs. Therefore, two… Expand
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Review
1987
Review
1987
SummaryThe pharmacokinetics of various drugs may be profoundly altered during different stages of pregnancy, parturition, and… Expand
1984
1984
No validated method exists for measuring lidocaine and its metabolites in myocardial tissue. We modified a previously described… Expand
Highly Cited
1978
Highly Cited
1978
It has been shown that the antiarrhythmic and toxic effects of lidocaine may be in part dependent on its two active metabolites… Expand
Highly Cited
1975
Highly Cited
1975
Glycinexylidide (GX) is a metabolite of lidocaine that is frequently present in µg/ml concentrations in the plasma of patients… Expand
1974
1974
Gas‐liquid chromatographic methods have been developed for the estimation of lignocaine and its metabolites ethylglycylxylidide… Expand
Highly Cited
1973
Highly Cited
1973
Glycinexylidide (GX) has been identified in the urine of 8 patients treated with intravenous infusions of lidocaine. The… Expand