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glycinexylidide
Known as:
2-amino-2',6'-acetoxylidide
, glycylxylidide
National Institutes of Health
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Related topics
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2 relations
Broader (1)
Lidocaine
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis
Sara Martín
,
R. Orlando
,
M. Bertoli
,
P. Pegoraro
,
P. Palatini
Clinical pharmacology and therapeutics
2006
Corpus ID: 1653032
Highly Cited
2004
Highly Cited
2004
Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: Effects of liver function
R. Orlando
,
P. Piccoli
,
S. De Martin
,
R. Padrini
,
M. Floreani
,
P. Palatini
Clinical pharmacology and therapeutics
2004
Corpus ID: 24456351
Highly Cited
2004
Highly Cited
2004
Effect of lidocaine on the minimum alveolar concentration of isoflurane in dogs.
A. Valverde
,
T. Doherty
,
Jorge A Hernandez
,
W. Davies
Veterinary anaesthesia and analgesia
2004
Corpus ID: 2147562
OBJECTIVE To determine the influence of a low-dose constant rate infusion (LCRI; 50 microg kg(-1) minute(-1)) and high-dose CRI…
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Highly Cited
2000
Highly Cited
2000
High-performance liquid chromatography-tandem electrospray mass spectrometry for the determination of lidocaine and its metabolites in human plasma and urine.
M. Abdel-Rehim
,
M. Bielenstein
,
Y. Askemark
,
N. Tyrefors
,
T. Arvidsson
Journal of chromatography. B, Biomedical sciences…
2000
Corpus ID: 24297827
1988
1988
Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels.
P. Bennett
,
R. Woosley
,
L. Hondeghem
Circulation
1988
Corpus ID: 1484578
The modulated receptor hypothesis states that sodium channels have a specific receptor for antiarrhythmic drugs. Therefore, two…
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Highly Cited
1978
Highly Cited
1978
Lidocaine and its active metabolites
P. Narang
,
W. Crouthamel
,
N. Carliner
,
M. Fisher
Clinical pharmacology and therapeutics
1978
Corpus ID: 28374480
It has been shown that the antiarrhythmic and toxic effects of lidocaine may be in part dependent on its two active metabolites…
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Highly Cited
1975
Highly Cited
1975
Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide
J. Strong
,
Douglas E. Mayfield
,
A. Atkinson
,
B. Burris
,
F. Raymon
,
L. T. Webster
Clinical pharmacology and therapeutics
1975
Corpus ID: 32146479
Glycinexylidide (GX) is a metabolite of lidocaine that is frequently present in µg/ml concentrations in the plasma of patients…
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1974
1974
Gas‐liquid chromatographic estimation of lignocaine, ethylglycylxylidide, glycylxylidide and 4‐hydroxyxylidine in plasma and urine
K. Adjepon-Yamoah
,
L. Prescott
The Journal of pharmacy and pharmacology
1974
Corpus ID: 34682892
Gas‐liquid chromatographic methods have been developed for the estimation of lignocaine and its metabolites ethylglycylxylidide…
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Highly Cited
1974
Highly Cited
1974
Anti-arrhythmic effects of lidocaine metabolites.
R. Burney
,
C. Difazio
,
M. Peach
,
K. A. Petrie
,
M. J. Silvester
American heart journal
1974
Corpus ID: 32026464
Highly Cited
1973
Highly Cited
1973
Identification of glycinexylidide in patients treated with intravenous lidocaine
J. Strong
,
M. Parker
,
A. Atkinson
Clinical pharmacology and therapeutics
1973
Corpus ID: 41373374
Glycinexylidide (GX) has been identified in the urine of 8 patients treated with intravenous infusions of lidocaine. The…
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