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glycinexylidide

Known as: 2-amino-2',6'-acetoxylidide, glycylxylidide 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Lidocaine
analogs & derivatives

Papers overview

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Highly Cited
2006
Highly Cited
2006
Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis
Highly Cited
2004
Highly Cited
2004
Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: Effects of liver function
Highly Cited
2004
Highly Cited
2004
Effect of lidocaine on the minimum alveolar concentration of isoflurane in dogs.
OBJECTIVE To determine the influence of a low-dose constant rate infusion (LCRI; 50 microg kg(-1) minute(-1)) and high-dose CRI… 
Highly Cited
2000
Highly Cited
2000
High-performance liquid chromatography-tandem electrospray mass spectrometry for the determination of lidocaine and its metabolites in human plasma and urine.
1988
1988
Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels.
The modulated receptor hypothesis states that sodium channels have a specific receptor for antiarrhythmic drugs. Therefore, two… 
Highly Cited
1978
Highly Cited
1978
Lidocaine and its active metabolites
It has been shown that the antiarrhythmic and toxic effects of lidocaine may be in part dependent on its two active metabolites… 
Highly Cited
1975
Highly Cited
1975
Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide
Glycinexylidide (GX) is a metabolite of lidocaine that is frequently present in µg/ml concentrations in the plasma of patients… 
1974
1974
Gas‐liquid chromatographic estimation of lignocaine, ethylglycylxylidide, glycylxylidide and 4‐hydroxyxylidine in plasma and urine
Gas‐liquid chromatographic methods have been developed for the estimation of lignocaine and its metabolites ethylglycylxylidide… 
Highly Cited
1974
Highly Cited
1974
Anti-arrhythmic effects of lidocaine metabolites.
Highly Cited
1973
Highly Cited
1973
Identification of glycinexylidide in patients treated with intravenous lidocaine
Glycinexylidide (GX) has been identified in the urine of 8 patients treated with intravenous infusions of lidocaine. The… 
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