FAQ

glycinexylidide

Known as: 2-amino-2',6'-acetoxylidide, glycylxylidide 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1973-2017
02419732017

Related topics

Related topics

2 relations

Broader (1)

Lidocaine
analogs & derivatives

Related mentions per year

Related mentions per year

1949-2018
19401960198020002020
glycinexylidide
Lidocaine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?
BACKGROUND Lidocaine exerts antinociceptive effects when applied systemically. The mechanisms are not fully understood but… (More)
Is this relevant?
2004
2004
Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.
OBJECTIVES This study was designed (1) to evaluate the effect of a cytochrome P450 (CYP) 1A2 inhibitor, fluvoxamine, on the… (More)
Is this relevant?
2004
2004
Effect of lidocaine on the minimum alveolar concentration of isoflurane in dogs.
OBJECTIVE To determine the influence of a low-dose constant rate infusion (LCRI; 50 microg kg(-1) minute(-1)) and high-dose CRI… (More)
Is this relevant?
2000
2000
Plasma lidocaine, monoethylglycinexylidide, and glycinexylidide concentrations after epidural administration in geriatric patients.
BACKGROUND AND OBJECTIVES The purpose of this study was to evaluate the effect of age on the pharmacokinetics of lidocaine after… (More)
Is this relevant?
1988
1988
Competition between lidocaine and one of its metabolites, glycylxylidide, for cardiac sodium channels.
The modulated receptor hypothesis states that sodium channels have a specific receptor for antiarrhythmic drugs. Therefore, two… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1984
1984
Lipid solubility modulates pH potentiation of local anesthetic block of Vmax reactivation in guinea pig myocardium.
Current theories envision recovery from local anesthetic block of sodium channels via slow hydrophilic and fast hydrophobic paths… (More)
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
1984
1984
Simultaneous determination of lidocaine and its metabolites in plasma and myocardium.
No validated method exists for measuring lidocaine and its metabolites in myocardial tissue. We modified a previously described… (More)
Is this relevant?
1978
1978
Lidocaine and its active metabolites.
It has been shown that the antiarrhythmic and toxic effects of lidocaine may be in part dependent on its two active metabolites… (More)
Is this relevant?
1975
1975
Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide.
Glycinexylidide (GX) is a metabolite of lidocaine that is frequently present in mug/ml concentrations in the plasma of patients… (More)
Is this relevant?
1974
1974
Gas-liquid chromatographic estimation of lignocaine, ethylglycylxylidide, glycylxylidide and 4-hydroxyxylidine in plasma and urine.
 
Is this relevant?