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The effect of chronic renal failure (CRF) on the pharmacokinetics of lidocaine, a drug cleared almost exclusively by hepatic… Expand OBJECTIVE
To determine the influence of a low-dose constant rate infusion (LCRI; 50 microg kg(-1) minute(-1)) and high-dose CRI… Expand A sensitive, selective and accurate high-performance liquid chromatographic-tandem mass spectrometric assay was developed and… Expand The modulated receptor hypothesis states that sodium channels have a specific receptor for antiarrhythmic drugs. Therefore, two… Expand SummaryThe pharmacokinetics of various drugs may be profoundly altered during different stages of pregnancy, parturition, and… Expand No validated method exists for measuring lidocaine and its metabolites in myocardial tissue. We modified a previously described… Expand It has been shown that the antiarrhythmic and toxic effects of lidocaine may be in part dependent on its two active metabolites… Expand Glycinexylidide (GX) is a metabolite of lidocaine that is frequently present in µg/ml concentrations in the plasma of patients… Expand Gas‐liquid chromatographic methods have been developed for the estimation of lignocaine and its metabolites ethylglycylxylidide… Expand Glycinexylidide (GX) has been identified in the urine of 8 patients treated with intravenous infusions of lidocaine. The… Expand